Sentences with phrase «cultured human and mouse»

Not exact matches

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

After a few days, the cultured papillae were transplanted between the dermis and epidermis of human skin that had been grafted onto the backs of mice.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

The researchers found that PAI - 039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

«With this development, we are now able to culture both mouse and human organoids, providing a very powerful tool in our fight against pancreatic cancer,» explains Tuveson.

They demonstrated that, similar to mouse, Rac1 inhibition resulted in impaired branching and decreased expression of AXIN2 and FGFR2b in human lung cultures.

Because of the difficulties involved in harvesting and culturing adult human neurons, most research on DRG neurons has been done in mice.

The test drug slowed the growth of kidney cysts in two mouse models and in cell cultures of human kidney cysts, the study showed.

Microscopic images show that RMC - 1 prevented FOXM1 from entering the nucleus in cultured human airway epithelial cells and in mouse allergen - sensitized respiratory airways.

The research team then tested RMC - 1 in cultured human airway epithelial cells and mouse models of asthma (via injection into the animals» peritoneal cavities).

Ralph Brinster, part of the team at the University of Pennsylvania in Philadelphia that first cultured sperm stem cells in the lab, has written that culturing stem cells from human sperm is not far off — humans and mice, like other mammals, he says, require similar growth factors.

The cell cultures in the petri dishes are of human origin, and in some aspects resemble human brains more than the brains of lab animals such as rats or mice do.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

For cultured human cells and mice battling the toxin, manganese proved to be a lifesaver.

Rudolph Tanzi and Robert Moir, who study neurodegeneration at Harvard MGH, sought to test whether amyloid - β might protect mice, Caenorhabditis elegans nematodes, and human cells in culture from invasion by various microbes.

Cultured mouse, monkey, and human pluripotent cells can be driven down a retinal lineage as determined by the expression of marker genes, including the EFTFs [2]--[4].

They then inserted the spatially oriented human stem cells (human rsPSCs) into specific regions of partially dissected mouse embryos and cultured them in a dish for 36 hours.

The CRISPR / Cas system is amazingly versatile and has proven to edit the genome effectively not only in mice and flies, but also in monkeys and, yes, in human cultured cells.

Small, transient populations of these totipotent cells are found in both mouse and human cultured stem cells.

We use 3D stem cell («organoid») cultures from mice and humans to examine occurrence, level and molecular causes of CIN in cancer (Video 2).

The team found that DHEA speeds up the circadian rhythm in human cells, as well as in cultured cells and tissues of mice.

This group cultured human CD34 + cells in StemSpan ™ medium and cytokines as a pre-stimulation step ahead of electroporation, before xenotransplantation into mice or additional in vitro culture.

For mouse ILC3s, splenocytes from Rag1 - / - mice were sorted (Lin -(CD3, CD45R, CD11c, GR - 1, NK1.1) c - kit + Thy1.2 +) and cultured as described for human cells using recombinant mouse cytokines.

Both mouse and human iPSCs are similar to embryonic stem cells (ESCs) with respect to their morphology, cell behavior, gene expression, epigenetic status and differentiation potential both in culture and in vivo.

We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.

Experimental studies and a growing body of evidence has emerged demonstrating that synthetic α synuclein fibrils (both human and murine) are capable of «seeding» and propagating α synuclein pathology not only in α synuclein transgenic mouse models but importantly in non-transgenic (WT) neuronal cultures and mice (Luk, K.C. et al., 2012a; Luk, K.C. et al., 2012b; Volpicelli - Daley, L.A. et al., 2014).

And while the human and T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloAnd while the human and T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloand T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloand from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the blood.

Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations of aluminum in the amount of those measured in the human breast are able to transform cultured mammary epithelial cells, allowing them to form tumors and to metastasize.