Sentences with phrase «cumulative burden»

Unlike currently used statistical methods that count health conditions once at diagnosis, cumulative burden tracks individuals» multiple, recurring treatment - related health conditions.

«Cumulative burden provides us with a global view of tradeoffs between different treatment late effects that must be considered when designing new interventions,» Bhakta said.

And they go on to say: «These findings suggest that in patients with stable [coronary heart disease], long term mortality risk is related to the cumulative burden of psychological distress.»

This study focused on calculating the cumulative burden of cardiovascular disease in 670 pediatric Hodgkin lymphoma survivors based on a detailed health analysis of 348 individuals enrolled in the St. Jude Lifetime Cohort Study (St. Jude LIFE).

«Cumulative burden is a new tool for studying chronic illness in childhood cancer survivors or any patient population with significant morbidity, such as diabetes or HIV / AIDS.»

Cumulative burden should help researchers refine health screening guidelines for survivors and design clinical trials aimed at maintaining high cure rates while reducing the late effects of treatment.

Investigators also determined the cumulative burden for a comparison group of 272 St. Jude LIFE community volunteers who underwent the same health assessments.

Researchers created a measurement called «cumulative burden» to better capture the distribution and magnitude of chronic disease in childhood cancer survivors.

In fact, the cumulative burden of the most serious heart problems, including heart attacks, was similar for 30 - year - old survivors and 50 - year - old community volunteers.

The analysis showed that the cumulative burden of cardiovascular disease, including severe and life - threatening conditions, was greater among survivors at 30 and 50 years of age than among the comparison group.

Researchers used those and other clinical findings to calculate the cumulative burden by tracking the incidence and severity of cardiovascular disease.

Degenerative aging is a consequence of the progressive accumulation of damage to tissue cellular and molecular structures over time; specific diseases of aging emerge when the cumulative burden of such damage in a particular tissue exceeds the minimum required to sustain its core biological functions.

The Center on the Developing Child is particularly concerned about the needs of children who face the cumulative burdens of poverty, maltreatment, violence, racial and ethnic discrimination, and family mental illness.

However, Carolyn Fairbairn, director - general of the Confederation of Small Businesses, said: «With inflation rising and the cumulative burden weighing on businesses» shoulders, limited relief for firms hit hard by business rates falls short.»

The cumulative burden of multiple diagnoses (comorbidity) may be that it has been strongly associated with decreased well - being, compromised health and quality of life, and poor psychosocial adjustment (Kimberling & Ouimette, 2002).

[4] More than the experience of any one of these traumas, the cumulative burden over time of these threats is particularly damaging to physical and mental health.