For the interaction and network data we used three detailed signalling network
resources, SignaLink 2,25 Reactome, 26 and a cancer signalling network compiled by Cui et al. 10, as well as two more
global protein - protein interaction (PPI) networks, namely the manually
curated HPRD, 27
resource and the integrated dataset comprising DIP, 28 IntAct, 29 and BioGrid.30 All these networks have different compilation protocols and thereby provide partially different information.
Raiji Kuroda introduces the problems that affect international
curating in Japan which, like the West, possesses the
resources, but is regarded as «not doing enough to promote culture to match its economic power in
global society».