Sentences with phrase «current phase i trials»

«Many of the current Phase I trials for spinal cord injury are run in the acute phase, which is right after injury.

Not exact matches

Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian cancer.

Promising results of an earlier, initial, multicenter clinical trial of nivolumab, first reported in 2013 and directed by Brahmer, led to the current phase III trial of 260 patients treated at hospitals across the world.

Phase II trials for that vaccine candidate are set to begin within the next two months, so it will not likely be available to combat the current swine flu outbreak, which could kill as many as 90,000 Americans and land up to 1.8 million in the hospital, according to the President's Council of Advisors on Science and Technology (PCAST).

Indeed, the authors note the speed with which a second FDA - approved drug believed to have promise in subduing HIV, Deferiprone, has moved directly from tests in culture to a phase I human trial conducted in South Africa, thanks to previously published results now reinforced by additional research in culture described in the current paper.

In his current role, he combines population research and functional genomics strategies to inform drug development from preclinical through phase 3 trials.

These results support Afferent's current development strategy to initiate a Phase 2b clinical trial early in 2015.

This information was critical in the design and implementation of the current Phase 1 trial and will be of significant benefit in planning the Phase 2/3 clinical efficacy trial.»

Illustrating the tricky path current Alzheimer's research faces, the study was published literally hours after giant pharmaceutical company Merck announced the cancellation of a Phase 3 clinical trial surrounding a drug that targets the exact same enzyme.

The resulting 2724 trials were then categorized and core information collated, including: trial phase, cell source (autologous / allogeneic), current activity of the trial and responsible national regulatory agency.

Current phase I immunotherapy trials are underway to test the utility of inhibiting Cbl - b in PBMCs in the treatment of cancer patients (ClinicalTrials.gov: NCT02166255, NCT03087591).

Even once a drug makes it to late - phase clinical trials, patients must be followed for several years, or even a decade or more, to determine whether the new treatment is more effective than current treatments.

According to Col Jerome Kim, Walter Reed Army Institute of Research, US, who was also part of the lead group for the study, apart from the current four doses of vaccines that were given to subjects in the phase III clinical trials in Thailand, they are planning to give a booster does after six months to increase the strength of the vaccine.

Current clinical trials include combination of intrahepatic embolization and a radiosensitizer in patients with uveal melanoma and liver - only metastases, a phase I trial that evaluates a combination therapy of BCG with ipilimumab in Stage III / IV melanoma, and several landmark international trials including a phase II trial that evaluates combination immunotherapy with nivolumab & ipilimumab.

Current estimates are for the Phase I trial to start enrolling 240 participants early in 2015.

Our current efforts in the AST - VAC2 program are focused on progressing this product towards a Phase 1 / 2a clinical trial in non-small cell lung cancer in collaboration with Cancer Research UK (CRUK).

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

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Doses in the phase 1 trial were five to 10 times higher than those being given in the current trial.

Their current goal is to enter phase I clinical trials in 2 years.

San Diego, New York, and Los Angeles, January 12, 2015 — ViaCyte and JDRF announced today that the current and former ViaCyte team are being recognized by JDRF for their pioneering work in developing the VC - 01TM product candidate, an innovative treatment currently in a Phase 1/2 clinical trial for type 1 diabetes (T1D).

A phase 2 clinical trial recruited 497 patients with high cholesterol, 73 percent of which were already taking statins, the current standard treatment for those at risk of cardiovascular disease.

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Current rabies exposure immune prophylaxis includes a new treatment product tested in Phase 2 and 3 clinical trials in Israel.

Future studies should follow guidance on the development and evaluation of complex interventions (such as the Medical Research Council's guidance).76 The results of all phases of intervention development also need to be published alongside trial results, as current studies alone do not allow us to fully understand why interventions have not produced expected effects.