Sentences with phrase «current immunotherapies»

However, it could dramatically improve the efficacy of current immunotherapy drugs, which now have a 20 to 50 percent success rate.

Current immunotherapies for ovarian cancer fall into six broad categories: monoclonal antibodies; checkpoint inhibitors and immune modulators; therapeutic vaccines; adoptive T cell transfer; oncolytic viruses; and adjuvant immunotherapies.

Both memory T cells subtypes can be reactivated with current immunotherapy treatments, and reactivation of both requires DC1 dendritic cells.

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.

Stephan's nanoparticles also have the potential to help make current immunotherapies more effective by providing T cells with nanoparticle «backpacks» to carry the right mix of molecules that T cells need to survive and sustain a robust anti-cancer response.

Once they identified this pathway, Hanks and colleagues conducted laboratory tests of a molecule that blocks melanoma cells from going stealth, enabling the immune system to mount a direct attack while also enhancing the function of current immunotherapies such as pembrolizumab and nivolumab.

«We think this shows that epigenetic fate inflexibility may limit current immunotherapies based on PD - 1 checkpoint inhibitors,» said first author Kristen Pauken, PhD, a postdoctoral researcher in the Wherry lab.

To learn more about current immunotherapy treatment options for women with gynecologic cancers, and how close we are to making these treatments available to more patients, watch Dr. Odunsi's webinar from June 4, 2013.

Current immunotherapy approaches for melanoma fall into seven main categories: checkpoint inhibitors, oncolytic virus therapies, cancer vaccines, adjuvant immunotherapy, adoptive cell therapy, monoclonal antibodies, and cytokines.

In current immunotherapies, engineered T cells are infused intravenously into patients and then must begin hunting for their targets.

The ultimate goal of Dr Janji's research team is to provide the proof of concept that targeting autophagy could improve the efficacy of current immunotherapies, notably those based on immune checkpoint blockades.

Current immunotherapies for lymphoma fall into five broad categories: checkpoint inhibitors, adoptive cell therapy, monoclonal antibodies, therapeutic cancer vaccines, and cytokines.

This time Lin and his colleagues worked with mice with breast cancer, another form of cancer that often doesn't respond to current immunotherapy drugs.

It would likely explore whether the investigational drug might boost the success of current immunotherapies.

This treatment resistance may be caused by certain anti-NMDA receptor antibody - producing plasma cells that remain inaccessible to current immunotherapies.

Current immunotherapy is based the reactivation of these T lymphocytes; however, little is known about how they can be generated more effectively, and in particular how immune memory can be triggered to prevent the development of tumors and metastasis.»

Current immunotherapy is based on immune checkpoint inhibitors targeting CTLA4 and, in the last 5 years in PD1 / PDL1 interaction [11].

Current immunotherapies for brain cancer fall into six broad categories: cancer vaccines, checkpoint inhibitors, oncolytic virus therapy, adoptive cell therapy, adjuvant immunotherapies, and monoclonal antibodies.

Current immunotherapies for colorectal cancer fall into seven broad categories: checkpoint inhibitors and immune modulators, monoclonal antibodies, therapeutic vaccines, adoptive cell therapy, oncolytic virus therapy, adjuvant immunotherapies, and cytokines.

The current immunotherapies are subject to the immunosuppressive effects of cancer, which likely contribute to their lack of success.