Sentences with phrase «current levels of uncertainty»

«Given the current levels of uncertainty and associated volume of «worker or employment status» claims facing the gig economy, I understand why Deliveroo is raising this issue.

There is no doubt that we are in a time of particular challenge for business, not least because of the current level of uncertainty around Brexit.

Not exact matches

The legal tussle may well divide the on - demand economy into two camps: the fundamentally sound companies — the ones that can figure out how to compete on any sort of playing field, as long as it's level, because they're selling a real innovation — and the companies that exist only because the current haze of legal and regulatory uncertainty paired with free - flowing venture capital has permitted them to flourish.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Following the announcement, crude oil immediately spiked 2.5 percent over uncertainty of how this might affect the Middle Eastern kingdom's position on keeping oil production at current levels.

The current list of economic uncertainties is long enough without adding uncertainty about the general level of prices to the list.

So most probably, any uncertainty in the market picture will be resolved within about 5 % of current levels.

The current elevated level of geopolitical uncertainty, and the related prevailing uncertainties around the economic outlook, are likely contributing importantly to this continued underperformance in business investment.

Now the current levels of volatility have emanated from a number of different sources: political uncertainty, concerns about rising inflation, concerns about rising interest rates, concerns about a trade war, cybersecurity fears, all of these different things.

Their survey uncovered significant uncertainties in current climate projections of the intensity and vertical structure of the low - level convergence of moisture to and upper - level divergence of heat away from the tropics.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, the outcome of the review of the continued listing of our common stock on The Nasdaq Stock Market, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

Actual outcomes and results may vary materially from these forward - looking statements based on a variety of risks and uncertainties including: our dependence on key management and product development personnel, our dependence on our Grand Theft Auto products and our ability to develop other hit titles for current generation platforms, the timely release and significant market acceptance of our games, the ability to maintain acceptable pricing levels on our games, our ability to raise capital if needed and risks associated with international operations.

Actual outcomes and results may vary materially from these forward - looking statements based on a variety of risks and uncertainties including: our dependence on key management and product development personnel, our dependence on our Grand Theft Auto products and our ability to develop other hit titles for current and next - generation platforms, the timely release and significant market acceptance of our games, the ability to maintain acceptable pricing levels on our games, our ability to raise capital if needed and risks associated with international operations.

A comprehensive risk assessment would determine flood hazard for individual structures by modeling watershed and floodplain characteristics at fine spatial scales; it would describe the varying levels of protection offered by all elements of a flood protection system and mitigation measures; and it would account explicitly for uncertainties, including those related to current and future flood hazard, structure value and vulnerability, and the current and future performance of flood protection measures.

These revisions are one example of a strategy we saw Carson use consistently: Add uncertainty at the level of ignorance to destabilize the science, then articulate the harms, hazards, or consequences behind our current actions, and drive it home with a visceral image of risk (which she does in this example through images of liver damage, the accumulation of DDT in milk and butter, and the ability of toxic chemicals to pass to breast - fed human infants, and to a fetus in utero).

Unfortunately it shows, in my judgment, a current tendency by this group of scientists and their supporters to react by down grading some serious and basic statistical errors and inabilities to place uncertainty measures on results to a level of «minor» flaws and to characterize the criticisms as personal attacks.

Satellite data, which manifest the highest short - term rates of sea - level rise (but also great measurement uncertainties) belie your extravagant claims: the current rate is only 3.2 mm / year (https://climate.nasa.gov/vital-signs/sea-level/).

(3) Current estimates of surface and lower to mid-tropospheric temperature trends are subject to a level of uncertainty that is almost as large as the apparent disparity between them.

Current limitations of ice - sheet modelling also increase uncertainty in the projections of 21st - century sea - level rise (Meehl et al., 2007 Section 10.6.4.2) used to assess coastal impacts in this report.

Given the potential importance of West Antarctica to future global sea level and our current knowledge of glacier instability, why is there so much uncertainty about its future?

Although it is important to reduce the remaining climate uncertainties, such as the magnitude of the impacts of short - lived pollutants, it does not change the fact that CO2 is very likely the driving force behind the current global warming, or that if we double the amount of CO2 in the atmosphere from pre-industrial levels, the planet will likely warm in the range of 2 to 4.5 °C.

But the GENERAL level of warming (the big old uncertainty region) Exceeds the current warming and THAT is scientifically interesting.

It also contains a very high level of uncertainty, as current rate of annual SLR will give us a grand total of....

Uncertainty about the future climatic effect of carbon dioxide emissions consists of two parts: the future carbon dioxide concentration given current levels of emissions, and the amount of warming that can be expected from a given carbon dioxide concentration.