Sentences with phrase «currently in clinical trials»

There are three readily discernible components of value: 1) Net cash or the amount of cash left after liquidation of marketable securities and repayment of the LT debt and other liabilities, 2) The royalty revenue stream from the patented Customised Linker Technology (the PegIntron royalties) and 3) the intellectual property related to the four compounds currently in clinical trials as well as any other compounds in pre-clinical development.

In fact, medicines that combat the inflammatory mediators released from stress, such as TNF and IL - 6, are currently in clinical trials for the treatment of cancer.29 Once again, we don't have proof that stress causes cancer, but big pharma is putting their money where their mouth is and targeting the same inflammatory mediators that stress causes in order to treat cancer.

New, targeted treatments are currently in clinical trials.

«Our ultimate goal is for the new database to cover almost every available drug worldwide, including those currently in clinical trials,» said Huang, who is also a professor at the University of California, San Francisco.

The allosteric inhibitors specific for ABL kinases (which are currently in clinical trials) provide a potentially useful tool for selectively targeting ABL kinases in metastatic breast cancer types with an increase in the ABL pathway signature (58).

A new UC San Francisco study has shown that a cancer - killing («oncolytic») virus currently in clinical trials may function as a cancer vaccine — in addition to killing some cancer cells directly, the virus alerts the immune system to the presence of a tumor, triggering a powerful, widespread immune response that kills cancer cells far outside the virus - infected region.

Researchers from Ruhr - University Bochum in Germany have reported that a drug currently in clinical trials for multiple sclerosis is neuroprotective in two mouse models of Huntington's disease.

It is currently in clinical trials to test its efficacy with a broader range of MDS patients.

Dr. Srivastava has co-founded a biotechnology company to help find new cures for many human diseases and one of the developmental genes whose role he discovered, Thymosin β4, is currently in clinical trials for patients suffering ischemic damage to the heart.

A glycolipid that activates these cells is currently in clinical trials in Australia, Japan, and Europe for treatment of metastatic cancer and hepatitis C virus infection.

Scientists searching for new drugs to fight malaria have identified a number of compounds — some of which are currently in clinical trials to treat cancer — that could add to the anti-malarial arsenal.

For instance, gold is used in therapies for certain cancers and rheumatoid arthritis, while other metal - based treatments are currently in clinical trials.

Several of the compounds are currently in clinical trials to treat cancers like leukemia and myeloma.

This new drug — AZD3965 — is currently in clinical trials, but it has not yet been tested in small cell lung cancer.»

Millions of new chemical compounds have been tested for their ability to disrupt the growth of M. tuberculosis in the test tube, but discouragingly few are currently in clinical trials.

Several companies, including Second Sight in Sylmar, California, have developed prosthetic retinas, some of which are currently in clinical trials.

«Our next step is to see how long we can extend the cycling pattern, and test some of the STAT3 inhibitors currently in clinical trials for other indications such as cancer, as this could accelerate testing in humans,» added Sacco.

The drug, which is currently in clinical trials, blocks myostatin — and perhaps GDF11 as well.

Hh antagonists are currently in clinical trials for the treatment of several types of cancer.

Meanwhile the two potential Ebola vaccines, currently in clinical trials, will have initial safety data in November 2014.

One of these CDK2 inhibitors, kenpaullone, was more effective than four other compounds that are currently in clinical trials for treating hearing loss.

A non-hormonal option for male contraception is preferable to hormonal treatments currently in clinical trials, because the types of hormones that make men infertile have more severe side effects than those used in the female pill.

«The CDN we used in this study is currently in clinical trials,» he said.

Researchers found that AcK1 closely resembles ShK, a peptide from a sea anemone, which has been shown to suppress autoimmune diseases and is currently in clinical trials for the treatment of multiple sclerosis.

Several JAK2 inhibitors have already been approved by the FDA or are currently in clinical trials for the treatment of other cancers.

One potential drug, Tariquidar, is currently in clinical trials, but in the past, other potential drugs have failed at that stage.

Both drugs are currently in clinical trials.

AstraZeneca's AKT inhibitor is currently in clinical trials for prostate, breast and other cancers.

There are several drugs to treat ALS currently in clinical trials and we are hopeful that people living with ALS have even more therapies available to them sooner rather than later.»

There are more than 80 immune - related cancer therapies currently in clinical trials, fueled by many billions of dollars in pharmaceutical investment from the likes of Bristol - Myers Squibb bmy, Merck mrk, Pfizer pfe, and dozens of biotechs.

Indeed, this study shows that the therapeutic efficacy of a new drug that is currently in clinical trial depends on Sestrin1.

Symetis is also developing the ACURATE neo / AS ** next generation valve system, currently in a clinical trial intended to serve as the basis for a future CE mark application.

Not exact matches

Inovio's vaccine against HPV is currently in Phase II clinical studies, and Kim says «about 50 percent» of the subjects in that trial are defeating the disease.

Currently in the U.K., he will go back to Privateer's headquarters in Seattle, then visit Tilray's 60,000 - square foot facilities in British Columbia, Canada, then to Australia, where Tilray has an import license to send marijuana for a clinical trial with a chemotherapy - induced nausea and vomiting study with the University of Sydney, the government of New South Wales and the country's largest cancer hospital.

Woo counters that Maastricht University in the Netherlands is currently conducting a clinical trial studying his company's supplements, which will publish at ClinicalTrials.gov.

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

While Yervoy brought in $ 960 million in sales in 2013 (an enormous figure for a two - year - old drug with a small patient population), the company currently has more than 35 ongoing clinical trials investigating another drug that disengages the immune system's brakes: the much - awaited nivolumab, which was also from the Medarex portfolio.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Epic Sciences is currently involved in over 60 active clinical trials that aim to evaluate CTCs in a number of different cancer indications.

MSDC - 0602K is currently being evaluated in a Phase 2b clinical trial.

If we are required by the FDA, the EMA, or other regulatory authorities to perform studies in addition to those we currently anticipate, or if there are any delays in completing our clinical trials or the development of our current product candidates, our expenses could increase and our ability to generate revenue could be further delayed.

Celgene's drugs are currently in over 160 clinical trials, including 42 novel compounds across 60 indications.

Since the neuronal death can be recapitulated in directly reprogrammed patient neurons, Yoo said the new technique offers a way to study the details of how potential therapies — including drugs that are currently being tested in clinical trials — could rescue medium spiny neurons from death.

While they were able to block DOT1L directly using an inhibitor substance currently being tested in a clinical trial for a different type of leukemia, a direct drug - based inhibition of MLL proved impossible.

There, he made anticancer compounds, two of which are currently in phase I and phase II clinical trials.

Drug candidates currently in late stage clinical trials comprise of growth factors, which are traditional protein - based biological drugs associated with high costs, and some trials have been prematurely terminated.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

Drug derivatives of JQ1 are currently being tested in clinical trials for people with cancer.

In fact, psilocybin is currently being tested in clinical trials for depressioIn fact, psilocybin is currently being tested in clinical trials for depressioin clinical trials for depression.

(This treatment isn't currently available in the United States, Kawaoka says, though polymerase inhibitors have been tested in clinical trials.)