Thermal proteome profiling (TPP) identified the protein targets of the Hsp90 inhibitor XL888 (
currently used in clinical trials) in a pair of sensitive and unresponsive cell lines.
We used these to repaper contracts for six of the world's largest banks as part of uncleared margin reform, and also
currently use them in our Clinical Trial Agreement and M&A solutions.
Not exact matches
While they were able to block DOT1L directly
using an inhibitor substance
currently being tested
in a
clinical trial for a different type of leukemia, a direct drug - based inhibition of MLL proved impossible.
«The CDN we
used in this study is
currently in clinical trials,» he said.
A non-hormonal option for male contraception is preferable to hormonal treatments
currently in clinical trials, because the types of hormones that make men infertile have more severe side effects than those
used in the female pill.
In a randomized, controlled clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well - tolerated in childre
In a randomized, controlled
clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics
currently approved only for
use in adults, is effective and well - tolerated in childre
in adults, is effective and well - tolerated
in childre
in children.
So - called phage therapy is widely
used in Eastern Europe and is
currently undergoing one U.S.
clinical trial.
Tengion develops human «neotissues and neoorgans»
using their Autologous Organ Regeneration Platform, and
currently has several ongoing preclinical and
clinical trials in the area of bladder and kidney augmentation and blood vessel replacement.
A
clinical trial studying the
use of Verapamil (a drug
currently in use for cardiovascular disease and cluster headache)
in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement
in the symptoms of this subset of patients.
Currently, the
use of the bacterium Listeria monocytogenes to break the immune tolerance of pancreatic tumors is being explored
in clinical trials and T. gondii may be similarly useful.
Since HDAC inhibitors are
currently in clinical use for cancer and are
in trials for treatment of metabolic and neurological diseases, these new findings call for a re-thinking about how they work, say the authors.
Industry representatives argue that the ethical and scientific procedures they
currently use for human pesticide tests are no different from those employed
in clinical trials of drugs.
For instance, gold is
used in therapies for certain cancers and rheumatoid arthritis, while other metal - based treatments are
currently in clinical trials.
While combining anti-cancer drugs appears a promising strategy, the sheer volume of drugs
currently in use or
in development — more than 500, which could make up more than 100,000 two - drug combinations — makes testing each potential combination
in clinical trials challenging.
The researchers are
currently seeking funding for the next step
in their project, which is to conduct
clinical trials using this data - driven detection method.
Dr. Xianmin Zeng is
currently in discussions with the NIH (National Institutes of Health) Center for Regenerative Medicine and the NIH Clinic Center on
using the cells for a Phase I
clinical trial.
Some treatments are standard (the
currently used treatment), and some are being tested
in clinical trials.
From the 128 drugs, 62 drugs are already under
clinical trial against cancer, and two (Dasatinib and Vandetanib) are
currently used in practice according to our literature survey.
Although Tobi will never fully regain the
use of his legs, he has benefitted from a
clinical trial involving stem cell transplantation
in dogs that is
currently underway at North Carolina State University.
The FDA
currently has a loophole (officially known as the 510 (k) regulatory pathway)
in place that allows manufacturers like DePuy to skip
clinical trials if they can show that the new device is «substantially equivalent» to similar devices already
in use.