The reverse was true, too: Saccharin blocked TAS2R1 — one of the bitter receptors that
cyclamate activates.
It turns out that saccharin doesn't just activate sweet taste receptors, it also blocks bitter ones — the same bitter taste receptors that
cyclamate activates.
In this case, though, the amount of saccharin required to block the receptors that
cyclamate activates would have bitter effects on its own.
Not exact matches
Previous studies of the two sweeteners had shown that saccharin alone
activates the subtypes TAS2R31 and TAS2R43, and
cyclamate tickles TAS2R1 and TAS2R38.
But
cyclamate doesn't just
activate the two bitter receptors, Behrens and his colleagues showed.