Pituitary
adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.
Concentration - dependent inhibition of
adenylyl cyclases by purified Gi alpha subunits is described.
The gaseous phase of cigarette smoke induced a 2 - to 36-fold increase in the activity of
guanylate cyclase in supernatant and particulate fractions from various rat and bovine tissues over basal activity.
The effects of prior stress on anxiety - like responding to intra-BNST pituitary adenylate
cyclase activating polypeptide in male and female rats King SB, Lezak KR, O'Reilly M, Toufexis DJ, Falls WA, Braas K, May V, Hammack SE.
The data raise the possibility of a role of octopamine - sensitive adenylate
cyclase in the physiology of synaptic transmission.
The characteristics of this phenomenon paralleled those of the activation of guanylate
cyclase by nitric oxide, which is a component of tobacco smoke.
The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl
cyclase system.
These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating
adenyl cyclase activity in the plasma membrane.
This resulted in increased basal myocardial adenylyl
cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol.
Systematic analysis of
diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0 - 1.
Its lead product candidate includes plecanatide a phase 3 guanylate
cyclase C, or GC - C, receptor agonist, designed to treat GI disorders, primarily chronic idiopathic constipation, or CIC, and constipation - predominant irritable bowel syndrome, or IBS - C.
His doctoral research focused on the regulation of the ERK / MAPK pathway by adenylyl
cyclases during long - term memory formation and sensitization to drugs of abuse.
A complementary DNA clone encoding the alpha subunit of the adenylate
cyclase stimulatory G protein (Gs) was isolated and identified.
This enzyme appears to be distinct from two other adenylate
cyclases present in the same tissue, which are activated by dopamine and by 5 - hydroxytryptamine, respectively.
Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate
cyclase cascade.
The newly developed CB1 receptor selective antagonist SR141716A was found to reverse cannabinoid agonist (WIN55212 - 2 or CP55940)- induced adenylyl
cyclase inhibition.
The Groups II and III of glutamate receptor membranes are coupled to the intracellular G - protein subunit, these mediate the inhibition of adenylyl cyclase [40, 41].
Clary Sage extract - Clary sage is also known as Salvia Sclarea, which is a potent adenylate
cyclase activator - meaning that it increases the enzyme action of forming cylic AMP (cAMP - cyclic adenosine monophosphate) from ATP.
Volume overload induces differential spatiotemporal regulation of myocardial soluble
guanylyl cyclase in eccentric hypertrophy and heart failure.
The plasma membrane of hepatic parenchymal cells contains an adenyl
cyclase system that is stimulated by glucagon.
An
adenyl cyclase activated by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion.
Research Interests: Inflammation; Nitric oxide; Heme transport; Soluble
guanylate cyclase; Electron transfer
Octopamine - Sensitive
Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous Tissue
The primary source of cyclic GMP in the intestinal lining is called Guanylyl -
cyclase C (GCC).
The cannabinoid receptors are members of the guanine - nucleotide - binding protein (G - protein) coupled receptor family, which inhibit adenylate
cyclase activity in a dose - dependent, stereoselective and pertussis toxin - sensitive manner.
Evidence suggests that both alpha and beta gamma subunits of heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) inhibit
adenylyl cyclase.
Desensitized beta - adrenergic receptors showed a 40 to 50 percent reduction in their ability to couple to the heterologous
adenylate cyclase system, comparable to the reduction in their functionality observed in their original membrane environment.
In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl
cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma.
G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl
cyclase.
Adrenocorticotropin and epinephrine do not stimulate this adenyl
cyclase, and very little cyclic phospho - diesterase activity is present in the membrane.
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase
The GTP - alpha subunit complex activates appropriate effectors, such as adenylyl
cyclase, retinal phosphodiesterase, phospholipase C, and ion channels.
Although type I adenylyl
cyclase is inhibited directly by exogenous beta gamma, inhibition of adenylyl cyclase by Gi alpha has not been convincingly demonstrated in vitro.
An adenylate
cyclase that is activated specifically by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system.
The characteristics of the inhibitory effect were dependent on the type of adenylyl
cyclase and the nature of the activator of the enzyme.
The concentrations of Gi alpha required to inhibit adenylyl
cyclase were substantially higher than those normally thought to be relevant physiologically.
Adenylyl
cyclase (AC) converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate, a ubiquitous second messenger that regulates many cellular functions.
Cigarette smoke activates guanylate
cyclase and increases guanosine 3», 5» - monophosphate in tissues
Long - term exposure of various cell types to beta - adrenergic agonists such as isoproterenol leads to an attenuated responsiveness («desensitization») of the adenylate
cyclase system to further challenge with these agonists.
The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate
cyclase.
A team of French and American scientists at several institutes pinpointed mutations in the retinal guanylate
cyclase (RETGC) gene in eight families in which the disease has struck.
Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate
cyclase — which mediate phototransduction, the process of converting light into an electrical signal.