The characteristics of this phenomenon paralleled those of the activation of guanylate
cyclase by nitric oxide, which is a component of tobacco smoke.
Although type I adenylyl cyclase is inhibited directly by exogenous beta gamma, inhibition of adenylyl
cyclase by Gi alpha has not been convincingly demonstrated in vitro.
Concentration - dependent inhibition of adenylyl
cyclases by purified Gi alpha subunits is described.
Not exact matches
His doctoral research focused on the regulation of the ERK / MAPK pathway
by adenylyl
cyclases during long - term memory formation and sensitization to drugs of abuse.
The alpha 2 and beta 2 adrenergic receptors, both of which are activated
by epinephrine, but which can be differentiated
by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl
cyclase system.
In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl
cyclase, one form of adenylyl
cyclase was inhibited
by beta gamma, some forms were activated
by beta gamma, and some forms were not affected
by beta gamma.
The plasma membrane of hepatic parenchymal cells contains an adenyl
cyclase system that is stimulated
by glucagon.
These findings support the concept that glucagon exerts its regulatory action in the liver
by stimulating adenyl
cyclase activity in the plasma membrane.
An adenylate
cyclase that is activated specifically
by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system.
This enzyme appears to be distinct from two other adenylate
cyclases present in the same tissue, which are activated
by dopamine and
by 5 - hydroxytryptamine, respectively.
An adenyl
cyclase activated
by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion.
The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced
by forskolin, an activator of adenylate
cyclase.
Scaffolding
by A-kinase anchoring protein enhances functional coupling between adenylyl
cyclase and TRPV1 channel.
Molecular cloning has demonstrated that dunce codes for the enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl
cyclase; DCO codes for the catalytic subunit of protein kinase A, and CREB a transcription factor that is phosphorylated and activated
by protein kinase A.
Receptor molecules coded
by the 7 - repeat allele have been found to have a lower potency for dopamine - mediated coupling to adenylate
cyclase than receptors encoded
by the other frequent, 2 - or 4 - repeat forms [90], and more recent results suggest an additional effect of the 48 bp VNTR on gene expression [91, 92].