Sentences with phrase «cycle of cell damage»

Not exact matches

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

It is therefore essential that there be control mechanisms capable of detecting errors in this process and halting the cell cycle with the aim of allowing the cell to repair the breakages or, if not possible, to eliminate the damaged cell.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

Johan Auwerx's team showed that the disease leads to a second cycle of events inside the cells, a series of reactions that exacerbate the disease's damaging effects.

Prof. Umeda found that inhibiting CDKs even with the absence of DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.

Senescent cells have removed themselves from the cycle of replication in reaction to cell and tissue damage, or a local tissue environment that seems likely to result in cancer.

The Effect of a DNA Damaging Agent on Embryonic Cell Cycles of the Cnidarian Hydractinia echinata.

Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae.

The researchers speculated that in brain cells, cycles of DNA damage and repair facilitate learning and memory, whereas an imbalance between damage and repair disrupts these functions.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Finally, we show that inactivation of DNA damage checkpoint kinases in senescent cells can restore cell - cycle progression into S phase.

In response to a variety of stress signals, including nutrient deprivation, oxidative stress, dysfunctional telomeres, DNA damage and oncogene overexpression, normally dividing cells can permanently withdraw from the typical cell cycle.

Despite the presence of the cell's antioxidant defense system to counteract oxidative damage from ROS, oxidative damage accumulates during the life cycle and has been implicated in aging and age - dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders and other chronic conditions.

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

The AGEs destroy cell membrane function and damage insulin receptor activity creating a vicious cycle of elevated blood sugar and inflammatory stress.

This starts a chain reaction of excess toxins and acids which cause irritation of the small intestine cells damaging them and causing food absorption issues which only helps to continue the cycle.