Sentences with phrase «cycle related genes»
Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.
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The scientists compared the genetic sequence of five related strains of the species, looking for orphan genes and examining the life cycles of the various genes in the fly genome.
CLOCK is an acronym for «Circadian Locomotor Output Cycles Kaput,» because it is a central regulator of gene expression related to the body's circadian rhythm of sleeping and waking.
In fact, the researchers found gene expression differences between ASD and non-ASD in genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cycle.
Four strategies for gene expression are apparent during the parasites» life cycle: (i) housekeeping; (ii) host - related; (iii) strategy - specific related to invasion, asexual replication, and sexual development; and (iv) stage - specific.
Instead, they discovered that each V. carteri cell type expresses orthologs of genes from different temporal phases of the light — dark cycle in a related unicellular alga, Chlamydomonas reinhardtii, with somatic cells enriched for expression of dark - phase genes, and gonidial cells enriched for expression of light - phase genes.
Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42
cell type expresses orthologs of genes from different temporal phases of the light — dark cycle in a related unicellular alga,
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.