Sentences with word «cyclin»

Malignant cases of GII revealed strong positive expression of Cyclin D1 in invasive ductal epithelial cells and stroma, while negative stain was seen in the invader cells with vesicular polymorphic nuclei (Figure 2C).
It is critically important to understand how a genetic pathway actually functions and the consequences of interrupting it, especially in this case where there are multiple drug inhibitors of cyclin D being tested in clinical trials for breast cancer.
The researchers concluded from these findings that aberrant activation of cyclin E / Cdk2 oncogenic signaling is essential for maintaining and expanding the CD44 + / CD24 - / Low subpopulation in inflammatory breast cancer.
In a paper published online in Diabetes on January 26, biologists in the labs of Joslin Principal Investigator Rohit N. Kulkarni, M.D., Ph.D., and Anil Bhushan, Ph.D., at the University of California at Los Angeles used a genetic approach to show that a protein called cyclin D2 is needed for this beta - cell response in mice.
After identifying the cells, the researchers inhibited a protein in them, called cyclin D1, which allows them to self - renew and differentiate.
As their name suggests, these proteins are regulated by cyclins.
Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.
Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R: Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube - derived high - grade serous ovarian cancers.
A large number of hippocampal neurons were stained with cyclin - dependent kinase 5 in the offspring from the ethanol - treated group (immunofluorescence, x 400).
In this study, it is shown that dephosphorylation of Tyr15 triggered activation of the pp34 - cyclin complex from fission yeast, that a human protein - tyrosine phosphatase can catalyze this event both in vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylation.
By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.
We also need to know if there are other non-HRD factors, such as cyclin E positivity, that predict which patients will respond to treatment.
Normal cells keep E2F levels in check with a protein called pRB and an enzyme called cyclin A-cdk2.
Cell division is notably regulated by specific genes, including the proto - oncogenes Cyclin E and Myc.
Western blot analysis following treatment with rapamycin (B) or transient transfection with mTOR siRNA (C) showed increased levels of the CDK inhibitors p21waf1 and p27kip1, underphosphorylated retinoblastoma protein, and decreased cyclin A in a dose - dependent manner.
Equal amounts of single or mixed populations of recombinant TFIIHs (containing XPD, XPB, p62, p52, His - p44, Flag - p34, cdk7, cyclin H, Mat1, and p8) were mixed with recombinant XPG, XPF / ERCC1, XPC / hHR23B, RPA, and a radiolabelled synthetic NER substrate.
Specifically, it inhibits cyclin - dependent kinase 4 (CDK4) and closely related CDK6; two factors that are essential to drive cells into DNA replication phase.
CCND1, which encodes cyclin D1, is amplified in a number of melanomas with wild - type BRAF and NRAS.
His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.
Identified cyclins in herpesviruses that can stimulate continuous cell - cycle progression, providing a novel example of how viruses are able to hijack host machinery to induce malignancy in mammalian cells
They found that CD44 + / CD24 - / Low cancer stem cells (CSCs) were resistant to conventional chemotherapy but were sensitive to SU9516, which is a specific cyclin - dependent kinase 2 (Cdk2) inhibitor.
The only thing I know I'm really good at is spotting little things that don't make sense, like that double - stranded RNA thing, or the protein that I saw going away on the original cyclin gel, even though it wasn't what I'd been looking for, and the dogma of the time said that proteins didn't go away.
In the current study, Lu and her colleagues show that a protein complex named cyclin B1 / cdk1, which is expressed at high levels in the cytoplasm of advanced melanomas, induces a pair of precise chemical modifications on iASPP to activate the protein.
This led me to enter the field of developmental and cell biology, and to eventually discover cyclin as a key regulator of the cell cycle.
For some reason, pRB is turned off in all types of cancer cells, leaving them with only cyclin A-cdk2 to regulate E2F.
Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer.
When these mice were crossed with mice lacking cyclin D2, all their progeny developed diabetes because they produced dramatically fewer beta cells.
It is still unclear whether cyclin D2 is expressed in human beta cells, so the researchers next will look for its analog in humans.
«In that case, it will be extremely useful to identify proteins like cyclin D2 that are helpful for replication.»
Zoledronic acid augments the radiosensitivity of cancer cells through perturbing S - and M - phase cyclins and p21CIP1expression.
Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1 - Cdk4 controls glucose metabolism independently of cell cycle progression.
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