Sentences with phrase «cyclin e»

KEYWORDS: Ovarian cancer, Genomics / Epigenomics of precursor lesions, Cyclin E, Replication Stress, BRCA1 / 2, DNA Repair, Protein complexes, Biomarkers, Animal models.

Activated E2F leading to transcription of several target genes including cyclin E in late G1 phase which form active complex with CDK2 drives progression from G1 to S phase [7].

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

The activation of the oncogenes Cyclin E or Myc, on the other hand, induces the cells to begin replication of their DNA prematurely, without having had time to eliminate all the replication origins present in the genes.

We also need to know if there are other non-HRD factors, such as cyclin E positivity, that predict which patients will respond to treatment.

The researchers concluded from these findings that aberrant activation of cyclin E / Cdk2 oncogenic signaling is essential for maintaining and expanding the CD44 + / CD24 - / Low subpopulation in inflammatory breast cancer.

Not exact matches

On one hand, it is an activator of the CDKs involved in early G1 (CDK4 and CDK6 associated to D cyclins), whereas on the other hand, it is an inhibitor of the CDKs involved in the G1 - S transition (CDK2 associated to E and A cyclins).

Del Sal G, Murphy M, Ruaro E, Lazarevic D, Levine AJ and Schneider C. Cyclin D1 and p21 / waf1 are both involved in p53 growth suppression.

Undifferentiated ES cells are also characterized by elevated levels of transcripts encoding the G1 / S transition - promoting complex cyclin E1: Cdk2 and, by contrast, low levels of transcripts encoding D - type cyclins and Cdk4 / 6 inhibitors of the INK4 family (p15, p16, p18, p19; Figure 7).