Sentences with phrase «cyclin dependent»

Calcitriol induces G0 / G1 arrest, modulates p27Kipl and p21Waf1 / Cipl, the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest.

Rb and E2F remain bound together as a result of cyclin dependent kinase inhibition.

mammalian target of rapamycin (mTOR); cyclin dependent kinase inhibitor - 2A

Glennie et al 134 have shown that T cells stimulated in co-cultures with MSC exhibit an extensive inhibition of cyclin D2 and upregulation of the cyclin dependent kinase inhibitor p27kip1.

Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

Not exact matches

Pfizer (pfe) breast cancer treatment Ibrance burst onto the scene in early 2015 and proceeded to dominate in a new therapeutic arena called cyclin - dependent kinase (CDK) 4 and 6 inhibitors.

(I keep waiting for the synthesis companies to make recommendations on their Web sites the way that Amazon and Netflix do: «If you liked the metalloprotease, you'll love this cyclin - dependent kinase!»)

They found that CD44 + / CD24 - / Low cancer stem cells (CSCs) were resistant to conventional chemotherapy but were sensitive to SU9516, which is a specific cyclin - dependent kinase 2 (Cdk2) inhibitor.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

Researchers from St. Jude Children's Research Hospital have discovered that inhibiting an enzyme called cyclin - dependent kinase 2 (CDK2) protects mice and rats from noise - or drug - induced hearing loss.

To understand how this accumulation occurs in response to DNA damage, the scientists considered the role of CDK, or cyclin - dependent kinases.

Dinaciclib is a member of a class of drugs known as cyclin - dependent kinase (CDK) inhibitors.

«We argue that metabolism and the cyclin - dependent kinase complex are coupled oscillators, which together orchestrate the growth and division of eukaryotic cells.»

The overall picture Heinemann and his colleagues have sketched in the Molecular Cell article is a system, in which the metabolic oscillator pulls the cyclin - dependent kinase complex through its cycle and dynamically gate the occurrence of the different cell cycle events.

All textbooks describe the cyclin - dependent kinase complex as the one and only / exclusive regulator of the eukaryotic cell cycle.

Or, in other words, the cyclin - dependent kinase complex is the orchestra, while the metabolic oscillations beat the rhythm, like a conductor does.

In experiments on baker's yeast, Harbauer discovered that a cyclin - dependent kinase phosphorylates a mitochondrial protein at the beginning of mitosis, meaning that the kinase modifies the protein to activate it.

Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin - dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin - dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.

THE STUDIES A trilogy of papers published in the September 28 issue of Nature examine the role of a protein — cyclin - dependent kinase inhibitor p16INK4a — in aging, healing, and cancer.

Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin - dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

A large number of hippocampal neurons were stained with cyclin - dependent kinase 5 in the offspring from the ethanol - treated group (immunofluorescence, x 400).

Among the serine - threonine kinases, p38, Rho - kinase, cyclin - dependent kinases, and Chk1 have been targeted with productive results for inflammation and cancer.

A randoMized phAse II trIal of fulvestraNt wiTh or without Ribociclib After progression on AntI-estrogeN therapy plus cyclin - dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive, HER2 negative breast cancer (MAINTAIN Trial)

Specifically, it inhibits cyclin - dependent kinase 4 (CDK4) and closely related CDK6; two factors that are essential to drive cells into DNA replication phase.

Cell cycle - dependent regulation of the forkhead transcription factor FOXK2 by CDK - cyclin complexes.

Other gene abnormalities were, on the other hand, encountered in the other groups, such as c - Kit [19], cyclin - dependent kinase 4 (CDK4) and cyclin D1 (CCDN1)[20, 21].

Cyclin - dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin - dependent kinases in Saccharomyces cerevisiae.

An InCytes from MBC Selection: Regulation of Cell Polarity through Phosphorylation of Bni4 by Pho85 G1 Cyclin - dependent Kinases in Saccharomyces cerevisiae.

Centrosome amplification in CHO and DT40 cells by inactivation of cyclin - dependent kinases.

Researchers from St. Jude Children's Research Hospital have discovered that inhibiting an enzyme called cyclin - dependent kinase 2 (CDK2) protects mice and rats from noise - or dr...

P16 binds to cyclin - dependent kinases 4 and 6 (CDK4 and CDK6) and inhibits phosphorylation of Rb, which remains associated with the transcription factor, E2F.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

DNA damage leads to a Cyclin A — dependent delay in metaphase - anaphase transition in the < i > Drosophila gastrula.

Cyclin - dependent kinases regulate splice - specific targeting of dynamin - related protein 1 to microtubules.

The cell cycle progression of eukaryotic cells is well controlled by cyclin, cyclin - dependent kinases (cdk), and cdk inhibitors.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

The cyclin - dependent kinase (CDK) inhibitors p21waf1 and p27kip1 and underphosphorylated retinoblastoma protein levels were up - regulated and cyclin A levels were decreased in a concentration - dependent manner (Fig. 5B and C).

Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin - dependent kinase inhibitor, in patients with refractory neoplasms.

His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

ONC201 induced caspase - dependent apoptosis that involved activation of the integrated stress response (ATF4 / CHOP) pathway, inhibition of Akt phosphorylation, Foxo3a activation, downregulation of cyclin D1, IAP and Bcl - 2 family members.

Cyclins form complexes with cyclin - dependent kinases (CDKs), unique to each cell - cycle phase, and activate specific genes to drive cells through their cycles.

Au - Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.: Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin - dependent kinase 2 and AKT inhibCyclin E1 amplified high grade serous ovarian cancer by cyclin - dependent kinase 2 and AKT inhibcyclin - dependent kinase 2 and AKT inhibition.

In particular, the upregulation of the cyclin - dependent kinase inhibitor p21Cip1 / WAF1 upon LA exposure was found to be required for its anticancer properties.