Sentences with word «cyclization»
Because many natural products of complex topology are biosynthesized by cyclization of modular linear precursors, which are in turn derived from iterative building block assembly, the authors hypothesized that an analogous linear to cyclized strategy could be used to access all fourteen types of structures presented here.
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Rather, you have to design whatever elements of structural information are necessary to get the right structure into your choice of one or more building blocks so that after the linear precursor goes through the final cyclization cascade, the pieces will all be where they should be.
Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic assembly lines, often attain the conformations that establish biological activity by cyclization constraints introduced by tailoring enzymes.
Porphyrin formation entails PBG deaminase - dependent HMB synthesis; limiting (or absent) expression of downstream enzymes in the heme biosynthesis pathway (grey) leads to non-enzymatic cyclization of HMB to form uroporphyrinogen I, as in the erythroid cells of CEP patients (Discussion).
Cre recombinase, originally named because it «causes recombination» (although later referred to as the «cyclization recombinase»), is a 38 kDa protein responsible for intra - and inter-molecular recombination at the loxP recognition sites.
CBT = cyclization ratio of branched tetraethers; MBT = methylation index of branched tetraethers; TEX86 = tetraether index of tetraethers consisting of 86 carbon atoms; Uk37 = 37, alkenone unsaturation index.
The evaluation of the CXCR4 inhibitory activities revealed that cyclization of the amine side chain only moderately affected their antiviral activity.
This causes cross-linking, cyclization, double - bond shifts, fragmentation, and polymerization of oils that cause far more damage than trans - fat.
In particular, the degree of cyclization and methylation among branched tetraethers is highly dependent upon pH and temperature, making fossil tetraether lipids an excellent proxy for reconstructing TSTs (Weijers et al., 2007)(see Appendix).