Sentences with phrase «cyclodextrin for»

Because cyclodextrin treatment in humans is safe (FDA approved application of 2 hydroxypropyl - β - cyclodextrin for the treatment of Niemann - Pick disease, type C. Phase I clinical trial) and cyclodextrin beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human atherosclerosis http://stm.sciencemag.org/content/8/333/333ra50.

Based on the results of this trial and past work, Ory said a larger phase three clinical trial — that is both randomized and controlled — is already underway investigating cyclodextrin for patients with NPC.

The Phase 2/3 trials will be sponsored by Vtesse, a new biotech company that was formed specifically to evaluate the safety and efficacy of cyclodextrin for the treatment of NPC and ultimately obtain FDA labeling if the drug is effective.

Not exact matches

For example, it should be easy to replace hydroxy (OH) groups with carboxy groups (COO --RRB- and so allow the cyclodextrin to form complexes with positively charged species.

«The difference between our material and activated carbons is that the cyclodextrins are actually much better for binding pollutants,» he says.

Doughnut - shaped cyclodextrin molecules used as catalysts, enzyme mimics, drug carriers and food stabilisers, have been studied for more than a decade.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

«Drug trial shows promise for deadly neurological disorder: Cyclodextrin slows progression of Niemann - Pick type C.» ScienceDaily.

Another three patients were given cyclodextrin in the spinal column every two weeks for 18 months.

In the combined phase one / two clinical trial, 14 NPC patients who were ages 4 to 23 years and showing neurological symptoms were given cyclodextrin, administered into the spinal column once per month for 12 to 18 months.

Chan emailed the twins» mother, who told him what to do to get Galya on the treatment, and then asked Wang if he'd be willing to apply on his daughter's behalf for compassionate use of cyclodextrin.

The Wikipedia page also linked to stories about twin 5 - year - old girls who in 2009 had become the first Americans to fight NPC with an experimental treatment called cyclodextrin — but only after their parents had spent years pressing for «compassionate use» of the investigational drug outside of a clinical trial.

Several months later, a few days before Christmas, Chan brought 2 - year - old Galya in for her weekly cyclodextrin treatment.

«Cyclodextrin is being developed as a drug for NPC, but it currently is being tested in the laboratory in other much more common conditions, including atherosclerosis and Alzheimer's disease.

Those researchers would not be studying cyclodextrin if not for the initial work that was done by the NPC community.»

The reason alpha - cyclodextrins lower postprandial glucose and cholesterol, and the reason they got relatively easy approval for use as food additives even in the EU, is because they aren't absorbed systemically: they work largely as soluble fiber does, binding excreted bile acids and slowing absorption of glucose.

[6] In 2013 the EU commission has verified a health claim for alpha - cyclodextrin.

α - Cyclodextrin has been authorized for use as a dietary fiber in the European Union since 2008.

Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.