Sentences with phrase «cyclodextrin in»

Another three patients were given cyclodextrin in the spinal column every two weeks for 18 months.

«Dr. Vite's studies provided important information on the potential of cyclodextrin in treating Niemann Pick Disease type C1,» Porter said.

Not exact matches

Now Fraser Stoddart of Northwestern University in Evanston, Illinois, and colleagues have devised a cage made of gamma - cyclodextrin, a ring of glucose molecules often used as a food additive (Angewandte Chemie, DOI: 10.1002 / anie.201002343).

Now researchers in the US have discovered how to modify cyclodextrins to take other chemical groups, opening the way to making related compounds with useful new properties.

Cyclodextrins have been used to deliver drugs because they can trap complex hydrophobic (greasy) molecules in their hydrophobic cavity.

The basic molecular unit consists of two main pieces: cyclodextrin (shown in blue in the figure below) and a six - carbon ring called tetrafluoroterephthalonitrile (red).

The porous cyclodextrin polymers reached 95 % of their adsorption capacity in just 10 seconds.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

But in studies of mouse models of the disease, cyclodextrins, even when administered peripherally, have significantly impacted the neurological damage; it's not known how.

Since cyclodextrin does not cross into the brain from the bloodstream, the drug must be in injected into the spinal column by lumbar puncture, an outpatient procedure often referred to as a spinal tap.

In the drug trial, researchers have shown that treatment with a type of sugar molecule called cyclodextrin slows progression of the disease.

In addition to demonstrating that disease progression slowed with cyclodextrin, Ory and his colleagues assessed biomarker measurements in the blood that showed evidence that the drug was removing cholesterol from the braiIn addition to demonstrating that disease progression slowed with cyclodextrin, Ory and his colleagues assessed biomarker measurements in the blood that showed evidence that the drug was removing cholesterol from the braiin the blood that showed evidence that the drug was removing cholesterol from the brain.

«We were at the time repeating published studies that had found that a certain drug dissolved in 2 - hydroxypropyl - beta - cyclodextrin, or HPβCD, was beneficial in the mouse model of NPC disease.

In the combined phase one / two clinical trial, 14 NPC patients who were ages 4 to 23 years and showing neurological symptoms were given cyclodextrin, administered into the spinal column once per month for 12 to 18 months.

A study coming out in Science Translational Medicine and led by University of Pennsylvania School of Veterinary Medicine researchers has shown that cats with NPC — which mirrors the human version of the disease — show vast improvements when treated with a compound called cyclodextrin.

Cyclodextrin is a sugar molecule that long has been used as a minor ingredient in many other pharmaceuticals because it helps drug compounds dissolve in water.

The Wikipedia page also linked to stories about twin 5 - year - old girls who in 2009 had become the first Americans to fight NPC with an experimental treatment called cyclodextrin — but only after their parents had spent years pressing for «compassionate use» of the investigational drug outside of a clinical trial.

Several months later, a few days before Christmas, Chan brought 2 - year - old Galya in for her weekly cyclodextrin treatment.

Cyclodextrin, more formally known as 2 - hydroxypropyl - beta - cyclodextrin, is the active ingredient in the air fresheCyclodextrin, more formally known as 2 - hydroxypropyl - beta - cyclodextrin, is the active ingredient in the air freshecyclodextrin, is the active ingredient in the air freshener Febreze.

PLAQUE BE GONE A sugar called cyclodextrin stopped cholesterol crystals (white) from building up in the arteries of mice on a high - fat diet.

«Cyclodextrin is being developed as a drug for NPC, but it currently is being tested in the laboratory in other much more common conditions, including atherosclerosis and Alzheimer's disease.

«Many of these drugs, including cyclodextrin, are still in the experimental stages.

Walenbergh SMA, Houben T, Hendrikx T, Jeurissen MLJ, Gorp van PJ, Vaes N, Olde Damink SWM, Verheyen F, Koek GH, Lütjohann D, Grebe A, Latz E, Shiri - Sverdlov R. Weekly Treatment of 2 - Hydroxypropyl - β - cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice.

The reason alpha - cyclodextrins lower postprandial glucose and cholesterol, and the reason they got relatively easy approval for use as food additives even in the EU, is because they aren't absorbed systemically: they work largely as soluble fiber does, binding excreted bile acids and slowing absorption of glucose.

[6] In 2013 the EU commission has verified a health claim for alpha - cyclodextrin.

α - Cyclodextrin has been authorized for use as a dietary fiber in the European Union since 2008.

My group is also working on A2E lipofuscin in the retina, and we've managed to remove it with a different treatment (using cyclodextrins).

Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.

http://onlinelibrary.wiley.com/doi/10.1002/asia.201600259/full Subcutaneous administration of cyclodextrin significantly improved spatial learning and memory deficits in Alzheimer disease mice model doi: 10.1084 / jem.20121239.

Because cyclodextrin treatment in humans is safe (FDA approved application of 2 hydroxypropyl - β - cyclodextrin for the treatment of Niemann - Pick disease, type C. Phase I clinical trial) and cyclodextrin beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human atherosclerosis http://stm.sciencemag.org/content/8/333/333ra50.