Doughnut - shaped
cyclodextrin molecules used as catalysts, enzyme mimics, drug carriers and food stabilisers, have been studied for more than a decade.
Cyclodextrin molecules are made from a ring of six, seven or eight hexagonal sugar units linked end to end.
Not exact matches
Now Fraser Stoddart of Northwestern University in Evanston, Illinois, and colleagues have devised a cage made of gamma -
cyclodextrin, a ring of glucose
molecules often used as a food additive (Angewandte Chemie, DOI: 10.1002 / anie.201002343).
The main component, beta -
cyclodextrin, is a naturally occurring bio-renewable sugar
molecule derived from cornstarch.
Cyclodextrins have been used to deliver drugs because they can trap complex hydrophobic (greasy)
molecules in their hydrophobic cavity.
However, it is the so - called «secondary» side of
cyclodextrins that is the real business end of the
molecule.
Vtesse is currently running a late - stage clinical trial of the drug, a large sugar
molecule known as a
cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).
It is a β -
cyclodextrin polymer, meaning it is composed of long strands of repeating
molecules.
The researchers modified the HA
molecules by attaching adamantane and
cyclodextrin groups to allow the gels to flow through catheters, and they added thiol and methacrylate groups to enable post-injection cross-linking to stiffen the hydrogel.
The Johns Hopkins team used a microshell made of a sugar - based polymer called
cyclodextrin to protect the 3BrPA drug
molecules from disintegrating early and to guard healthy tissue from the drug's toxic effects, such as weight loss, hypothermia and lethal hypoglycemic shock.
In the drug trial, researchers have shown that treatment with a type of sugar
molecule called
cyclodextrin slows progression of the disease.
Cyclodextrin is a sugar
molecule that long has been used as a minor ingredient in many other pharmaceuticals because it helps drug compounds dissolve in water.
It's a polymer made of repeated units of two different
molecules linked together: a giant ring - shaped
molecule called beta -
cyclodextrin that's made from cornstarch, and a fluorine - rich
molecule called decafluorobiphenyl, or DFB.