The reason alpha -
cyclodextrins lower postprandial glucose and cholesterol, and the reason they got relatively easy approval for use as food additives even in the EU, is because they aren't absorbed systemically: they work largely as soluble fiber does, binding excreted bile acids and slowing absorption of glucose.
Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β -
cyclodextrin to
lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.