Sentences with phrase «cyclooxygenase -2-overexpressing»

The enzyme that is inhibited is cyclooxygenase (abbreviated COX).

Second, cyclooxygenase (COX) is also responsible for maintaining the health of many tissues in the dog's body; for example, the lining of the stomach.

There are two types of cyclooxygenase: COX - 1 and COX - 2 inhibitors.

There are two main forms of cyclooxygenase: COX - 1 (which makes «good» prostaglandins) and COX - 2 (which makes the bad ones).

Previcox works by inhibiting the COX - 2 (cyclooxygenase - 2) enzyme which generates chemicals that are responsible for pain, inflammation and even fever in the body.

As mentioned, inflammation is mediated by prostaglandins (produced by cyclooxygenase) and leukotrienes (produced by 5 - lipoxygenase).

NSAIDs like Deramaxx repress the enzyme cyclooxygenase (COX).

It turns out that there are several types of cyclooxygenase, however.

When the inflammatory cascade is active, cells use their cyclooxygenase enzymes to begin to convert fats from their cell membranes into prostaglandins.

Ibuprofen is what is called a non-selective cyclooxygenase inhibitor, which means it inhibits all types of cyclooxygenase, not just the ones that produce inflammatory mediators.

Non-steroidal anti-inflammatory drugs (called NSAIDs) inhibit an enzyme called cyclooxygenase.

Deracoxib is an NSAID that acts specifically on the cyclooxygenase - 2 enzyme which has been shown to be the principal mediator of inflammatory processes.

Previcox (firocoxib) is a type of analgesic that acts by inhibiting the action of cyclooxygenase 2 which leads to the reduction in the formation or synthesis of prostaglandins and similar proinflammatory substances from arachidonic acid.

If the enzyme cyclooxygenase 1 (COX 1) transforms arachadonic acid, PG E1 prostaglandin is produced.

By inhibiting cyclooxygenase, thromboxane can not be produced and the platelets present at the time aspirin is given are permanently inactivated.

Although NSAIDs are a diverse group of drugs, they all work by blocking cyclooxygenase.

In the case of cyclooxygenase (COX), it stimulates cells to produce several substances, including prostaglandins, after the cells are damaged.

Rimadyl is designed to inhibit cyclooxygenase COX - 2, which generates prostaglandins involved in inflammation.

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX), an enzyme involved in the production of prostaglandins, some of which are mediators of the inflammatory response.

'' [NSAIDs] are strong inhibitors of the enzyme cyclooxygenase — COX — which is an important enzyme that is responsible for producing inflammatory mediators,» Etminan says.

Laboratory findings at Michigan State University suggest that ingesting the equivalent of 20 tart cherries inhibits enzymes called cyclooxygenase - 1 and -2, which are the targets of anti-inflammatory drugs.

Anti-Inflammatory Effects: Eugenol (one of basil's volatile oils) can also help block the enzyme cyclooxygenase (COX) in the body.

This normally is accomplished through enzymatic peroxidation, where enzymes found naturally in plant oils (i.e., lipoxygenase, cyclooxygenase) and animal fats (i.e., lipase) can catalyze reactions between water and oil.

Nettle also inhibited the inflammatory agents cyclooxygenase - 1 (COX - 1), cyclooxygenase - 2 (COX - 2), and prostoglandins.

(8) In another study, the anti-inflammatory properties of the active ingredient in schisandra, schisandrin, were shown to result from the inhibition of nitric oxide (NO) production, prostaglandin E2 (PGE2) release, cyclooxygenase - 2 (COX - 2) and inducible nitric oxide synthase (iNOS) expression.

Without cyclooxygenase, the swelling, discomfort and high temperature of inflammation do not take place.

They work by blocking the enzyme cyclooxygenase, which generates prostaglandins, according to MedicineNet.

In addition, older men will be encouraged by the finding that curcumin inhibits cyclooxygenase (COX), which is an enzyme that promotes inflammation and has been found to be the culprit in prostate cancer.

As mentioned previously, ginger properties include anti-inflammatory actions that stem from a group of compounds called gingerols, which work by inhibiting the prostaglandin - biosynthesizing enzyme, known as PH synthetase or cyclooxygenase (COX).

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase - 2 mediated through Toll - like receptors 4

The eugenol component of basil's volatile oils has been the subject of extensive study, since this substance can block the activity of an enzyme in the body called cyclooxygenase (COX).

It is mainly contained in the seeds and has been shown to inhibit cyclooxygenase - 2, an inflammatory protein related to a number of health conditions, including Benign Prostatic Hyperplasia (BPH).

Cyclooxygenase produces of a number of different compounds known as prostanoids (prostaglandins, prostacyclin and thromboxanes).

The prefix COX is short for cyclooxygenase, a pro-inflammatory agent.

As I illustrated above, arachidonic acid is processed by the enzyme cyclooxygenase (COX) to produce pro-inflammatory signaling molecules called eicosanoids, including leukotrienes, prostaglandins, and thromboxanes.

In addition, LA promoted inflammatory processes activating the nuclear factor - κB transcription factor as well as stimulating the expression of cyclooxygenase - 2 and pro-inflammatory cytokines.

So like NSAIDs, they're gonna — like they're non-steroidal so they're gonna help block these — these various cyclooxygenase enzymes --

Evans JF: Rofecoxib (Vioxx), a Specific Cyclooxygenase - 2 Inhibitor, Is Chemopreventive in a Mouse Model of Colon Cancer.

These acids decrease the body's production of a long list of pro-inflammatory biochemicals, including the same ones targeted by most NSAIDs — cyclooxygenase (COX 1 and 2).

At the same university, a follow - up study found that pine bark extract also inhibits COX - 1 and COX - 2 (forms of the enzyme cyclooxygenase) 4.

The drugs reduce pain and inflammation by inhibiting the cyclooxygenase (COX) enzymes, which are involved not only with inflammation but also with certain processes involved in cancer, such as blood supply to the tumor and programmed cell death (known as apoptosis).

Cyclooxygenase - 2 (COX - 2) is frequently overexpressed in human cancers and contributes to the malignant phenotype.

We have also investigated kahweol antiinflammatory potential through cyclooxygenase - 2 (COX - 2) and monocyte chemoattractant protein 1 (MCP - 1) modulation.

Autocrine / paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase - 2 and CD44 in cyclooxygenase -2-dependent invasion.

Cyclooxygenase 2 - dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer.

Role of p300 and PCAF in regulating cyclooxygenase - 2 promoter activation by inflammatory mediators.

Cyclooxygenase -2-dependent expression of angiogenic CXC chemokines ENA - 78 / CXC Ligand (CXCL) 5 and interleukin - 8 / CXCL8 in human non-small cell lung cancer.

Cyclooxygenase (COX, also referred to prostaglandin G / H synthase) is often the rate - limiting enzyme for the production of prostaglandins and thromboxanes from free arachidonic acid.

Additionally, two inflammation markers were determined, namely, the expression levels of cyclooxygenase 2 and the levels of secreted monocyte chemoattractant protein - 1.

Direct Transcriptional Up - regulation of Cyclooxygenase - 2 by Hypoxia - Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during Hypoxia