Sentences with word «cyclophosphamide»

Dr. Lewis has been Dartmouth PI on a first in man study of the combination of cyclophosphamide pretreatment with a humanized immunoconjugate of an anti-EpCAM antibody linked to two molecules of IL - 2.

Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte - macrophage colony - stimulating factor - secreting breast tumor vaccine: a chemotherapy dose - ranging study of safety and immune activation.

The scientists began to use post-transplant cyclophosphamide in clinical trials of fully matched bone marrow transplants in 2004.

A phase I / II trial of nivolumab (anti-PD-1) and low dose cyclophosphamide in progressive / relapsed pediatric solid tumors -LRB-

Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour.

«Surprisingly, the liver maintained a robust level of metabolic activity during methotrexate or cyclophosphamide treatment, but was nearly shut down in regards to fat production and fat storage,» adds Dr. Myers.

Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.

Juno said last night it will continue enrollment by returning to the trial's original protocol of using cyclophosphamide alone as a preconditioning drug.

Induction chemotherapy consisted of a short, 20 - week combination chemotherapy protocol including cyclophosphamide, doxorubicin, vincristine, L - asparaginase, and prednisone, as previously described [14].

Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft - versus - host (GVHD) disease in people who receive bone marrow transplants.

A course of the immunosuppressive drug cyclophosphamide reduced most of Luciana's swelling.

Patients given the 200 mg dose saw the most promising results and the study was able to conclude that, «phytochemicals from the avocado fruit can be utilized in making active chemoprotective ingredients (s) for lowering the side effect of chemotherapy like cyclophosphamide in cancer therapy».

The first step was to taper off immunosuppressives like prednisone and cyclophosphamide as quickly as possible.

«We've known for some time that giving cyclophosphamide after a transplant helps prevent GVHD, and our study provides an important piece of the puzzle for why it works.»

But the two most recent deaths leading to the second clinical hold occurred in November after resumption of the original cyclophosphamide - only protocol, which occurred when the ROCKET trial was resumed just 2 weeks after the first hold was imposed.

Johns Hopkins physicians also found that post-transplant cyclophosphamide enabled safe administration of new, half - matched bone marrow transplants in addition to traditional, fully matched ones.

The scientists also showed, in lab - cultured human cells, that an ALDH - blocking drug strips regulatory T - cells of their ability to grow and protect themselves from cyclophosphamide.

They found that cyclophosphamide kills all of the donor's transplanted bone marrow cells except for stem cells containing high levels of an enzyme called aldehyde dehydrogenase (ALDH).

Yet, scientists lacked an explanation for why post-transplant cyclophosphamide effectively curtailed acute and chronic GVHD.

Some of the first clues to how cyclophosphamide works were also discovered in the 1980s by Johns Hopkins scientists.

Once on cyclophosphamide, her parasites burgeoned.

It was only after starting cyclophosphamide, a last - ditch immunosuppressive, that Luciana's blight finally came clear.

Much like chemotherapy's well - known ability to decrease red and white blood cell precursors transiently, methotrexate or cyclophosphamide depleted fat cell precursors, leading to much decreased fat storage.

Among 10 women with advanced ovarian cancer who got injections of the personalized vaccine once every three weeks — with the medications cyclophosphamide and bevacizumab (marketed as Avastin)-- eight showed a strong immune response and were still alive after two years.

Kimmel Cancer Center researchers prove that high - dose cyclophosphamide therapy, administered alone (without bone marrow transplantation), is an effective therapy for many aplastic anemia patients.

According to some reports, the sulfasalazine drug (Azulfidine) prescribed to treat * pain and swelling, can lower sperm count while cyclophosphamide (Cytoxan) is also believed to affect fertility.

Recent studies have shown that the chemotherapeutic protocol comprising cyclophosphamide, vincristine, and prednisolone did not yield desired results.

The Chop protocol utilizes cyclophosphamide, doxorubicin, vincristine, and prednisone.

Exposure to topical insecticides and herbicides, obesity, cyclophosphamide administration and particular types of breed are believed to be the probable risk factors.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

Cancer - fighting drugs (cytotoxic drugs), including cyclophosphamide, methotrexate and doxorubicin, have toxic effects on cells and are commonly used in chemotherapy to kill cancer cells.

Johns Hopkins and other cancer researchers report that a very short course of a chemotherapy drug, called cyclophosphamide, not only can prevent a life - threatening immune response in some bone marrow transplant recipients, but also can eliminate such patients» need for the usual six months of immune suppression medicines commonly prescribed to prevent severe forms of this immune response.

Drugs like cyclophosphamide, and chlorambucil.

We know that chemotherapy with cyclophosphamide is a cause.

«Our findings may also lead to even wider acceptance of post-transplant cyclophosphamide,» he said.

The protocol of ZUMA - 1 calls for patients to receive fludarabine plus cyclophosphamide for 3 days before infusion of the target dose of KTE - C19, in which a patient's T cells are genetically modified to express a CAR that is designed to target the antigen CD1.

In the U.S. alone, nearly 400,000 patients of all ages receive cyclophosphamide and ifosfamide each year.

In this study, patients began treatment with chemotherapy using cyclophosphamide and topotecan and the experimental monoclonal antibody hu14.18 K322A.

One study used a pancreatic cancer vaccine with modified pancreatic cancer cells known as GVAX, alongside the chemotherapy drug cyclophosphamide and a special bacterium that boosts the immune response.

In the ROCKET trial assessing JACR015, the first clinical hold imposed in July followed the deaths of three patients, which the company blamed on a change to the trial's original protocol to precondition patients by using a combination of cyclophosphamide and fludarabine.

In a statement yesterday, Juno said it has asked the FDA for permission to change the trial protocol by ending the use of fludarabine as a preconditioning drug along with cyclophosphamide and going back to the trial's earlier protocol — changed during the second quarter — of cyclophosphamide preconditioning alone.

If you are receiving chemotherapy (especially cyclosporine, methotrexate, bromocriptine, cyclophosphamide, doxorubicin), have HIV disease, or take street drugs (especially PCP) talk to your doctor.