Sentences with phrase «cyclophosphamide after a transplant»
«We've known for some time that giving cyclophosphamide after a transplant helps prevent GVHD, and our study provides an important piece of the puzzle for why it works.»
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In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.
Patients receiving standard immunosuppressive drugs after transplant, as opposed to high - dose cyclophosphamide, have slower recovery of regulatory T - cells in their blood, adds Kanakry.
After the transplant, patients receive two days of cyclophosphamide to prevent GVHD and rejection of the new bone marrow.
Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.
Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.