Sentences with phrase «cyclophosphamide in»

Patients given the 200 mg dose saw the most promising results and the study was able to conclude that, «phytochemicals from the avocado fruit can be utilized in making active chemoprotective ingredients (s) for lowering the side effect of chemotherapy like cyclophosphamide in cancer therapy».

A phase I / II trial of nivolumab (anti-PD-1) and low dose cyclophosphamide in progressive / relapsed pediatric solid tumors (NCT02901145).

Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour.

The scientists began to use post-transplant cyclophosphamide in clinical trials of fully matched bone marrow transplants in 2004.

Not exact matches

Luznik and his team inventoried types of immune cells present in the blood of bone marrow transplant patients treated with post-transplant cyclophosphamide.

They found high levels of the regulatory T - cells in patients treated with post-transplant cyclophosphamide, and lab - cultured cells survived cyclophosphamide treatment.

Some of the first clues to how cyclophosphamide works were also discovered in the 1980s by Johns Hopkins scientists.

Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft - versus - host (GVHD) disease in people who receive bone marrow transplants.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

The scientists also showed, in lab - cultured human cells, that an ALDH - blocking drug strips regulatory T - cells of their ability to grow and protect themselves from cyclophosphamide.

Patients receiving standard immunosuppressive drugs after transplant, as opposed to high - dose cyclophosphamide, have slower recovery of regulatory T - cells in their blood, adds Kanakry.

Medical centers around the world now use the Johns Hopkins protocol of post-transplant cyclophosphamide, and Luznik says the inexpensive drug is becoming increasingly mainstream in bone marrow transplant regimens.

Luznik says that the researchers» next step will be to test the short course therapy in a phase III randomized clinical trial that would directly compare results in patients who receive the cyclophosphamide treatment with those who receive either a separate, experimental approach to prevent GVHD or the more traditional six - month immunosuppressive therapy.

Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.

Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.

Cisplatin and cyclophosphamide were the other drugs used in this study.

«Importantly, two chemotherapy agents — methotrexate and cyclophosphamide — could be dosed to completely reverse obesity without detectable toxicity, even in mice without cancer,» explains Dr. Myers.

To circumvent this problem, the investigators examined in mice whether a regimen of the chemotherapy drugs pentostatin and cyclophosphamide (PC) could block production of the antibodies that neutralize the anthrax toxin proteins.

In this study, patients began treatment with chemotherapy using cyclophosphamide and topotecan and the experimental monoclonal antibody hu14.18 K322A.

The combination of intermediate - dose cyclophosphamide (ID - CTX) and granulocyte colony - stimulating factor (G - CSF) fails to mobilize peripheral blood stem cells (PBSCs) in approximately 20 % of treated patients with multiple myeloma (MM).

Dr. Lewis has been Dartmouth PI on a first in man study of the combination of cyclophosphamide pretreatment with a humanized immunoconjugate of an anti-EpCAM antibody linked to two molecules of IL - 2.

This study established the MTD of the cyclophosphamide - huKS - IL2 combination (mainly limited by IL - 2 side effects), the pharmacokinetics of huKS - IL2 and its systemic immunologic and immunogenic effects in patients with solid tumors (BMC Cancer.

INTERACTIONS Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies.

Consuming kefir everyday for 4 months my rbc is raised 5 whole units (from 20 to 25 and still going, even three lines of treatments mtx, cyclosporine, cyclophosphamide didn't achive anything close to that), feel much better, sleep better, no infections (that's a big deal in my condition), my visits to WC regulised; 2 everyday, no stress, no gum desease (leukemias cause severe gum problems), no bad breath, my skin looks healthy, my pale colour dissapeared, i even go to gym 3 - 4 days per week and with goji berries these 2 working miracles on me.

This means steroids in high doses and other drugs such as azathioprine, cytarabine, mycophenolate, cyclosporin, and cyclophosphamide.

Ten of the 15 vaccinated dogs (66.7 %) in Group 2 that relapsed were treated with cyclophosphamide, vincristine, and prednisone (COP) as salvage therapy and four of these dogs (40 %) achieved durable second clinical remission (> 22 months) and did not relapse.