The moxFPs overcome the inherent problems of popular fluorescent proteins and were re-engineered by mutating
cysteine residues and N - glycosylation consensus sequences in popular FPs.
We and others have reported that FP
cysteine residues form inappropriate disulfide bonds in the secretory pathway (Figure 1)[4,6 — 8].
They are classified into four different categories, namely, CXC, CC, C and CX3C on the basis of the pattern of
cysteine residues in the chemokine ligands [6].
Gale and his colleagues wanted to find a form of Factor VIIIa protein that would be more stable, and they decided to try to make a mutant form of the protein with sulfur - containing
cysteine residues at strategic locations in two of the three chains.
The cysteine residues are vulnerable to modifications, a factor that contributes to the development of Alzheimer's.
These findings suggest that animal cells may have fail - safe mechanisms that prevent the surface expression of improperly folded proteins with unpaired or improperly bonded
cysteine residues.
When they examined the data, Shokat and his team found a previously undescribed pocket on the surface of K - Ras near
the cysteine residue.
The SNO reaction attaches a nitric oxide - like molecule to protein called PINK1, where the molecule attaches to a building block on PINK1 called
a cysteine residue.
Homocysteine and homocystine can attack an exposed disulfide bond or
cysteine residue, respectively, on proteins to form cysteine - homocysteine mixed disulfides, which may lead to the functional inactivation of the protein.
GSSH can also convert PTP 1B's redox - sensitive
cysteine residue into the inactive disulfide.
Not exact matches
To do this, cinnamaldehyde binds to two
residues of an amino acid called
cysteine on the tau protein.
Casein is a fractionated, poor - quality protein seriously deficient in
cysteine (a conditionally essential amino acid needed for immune support and detoxification) and rich in MSG and other dangerous
residues created during high temperature processing.