Sentences with word «cytarabine»

«Overall there appears to be a benefit of a fifth course of cytarabine in low - risk patients with AML,» said Kelly D. Getz, PhD, of the Children's Hospital of Philadelphia, who presented the results.

Crook KI, Early PJ, Messenger KM, Muñana KR, Gallagher R, Papich MG: The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes.

This observation raises the possibility that treatment regimens for AML, such as high - dose cytarabine, may be beneficial in treating this deadly malignancy.

A total of 200 liposomal cytarabine treatments, (median 4, range 1 — 4) were delivered to 66 patients.

The use of CPX - 351 reduced the risk of death by 31 % compared to the use of the chemotherapy drugs cytarabine and daunorubicin.

Removal of a fifth course of chemotherapy containing cytarabine resulted in worse overall survival and disease - free survival in pediatric patients with low - risk acute myeloid leukemia (AML), according to the results (abstract 10515) of a pooled analysis of two Children's Oncology Group (COG) trials presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, held June 2 — 6 in Chicago.

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF -?

The winner turned out to be the paper «Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies» (DOI: 10.1038 / nm.4265), presented by Sean Rudd.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

«Improvements in outcomes in pediatric AML have largely been attributed to intensification of cytarabine - and anthracycline - containing regimens and enhanced supportive care,» Getz explained.

Intraspinal treatment was liposomal cytarabine 50 mg administered by lumbar puncture at day 2 during the four HD - MTX courses.

Seventeen patients received GO alone when MRD was detected after two rounds of chemotherapy with the drugs cytarabine, daunorubicin and etoposide.

A Phase 1/2, Multicenter, Open - label Study of FT - 2102 as a Single Agent and in Combination with Azacitidine or Cytarabine in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome with an IDH1 Mutation

When used alongside standard chemotherapy agents daunorubicin and cytarabine in a treatment - resistant AML model, 99.7 percent of cancer cells were killed.

In this study, prior to giving intensive BEAM chemotherapy (which uses carmustine, etoposide, cytarabine, and melphalan), researchers collected stem cells from each patient's blood.

1) Rituximab was added to the induction as the majority of PCNSL are CD20 + diffuse large B - cell lymphomas (DLBCL) and it was previously shown that the addition of rituximab to CHOP chemotherapy has improved the prognosis in DLBCL outside the brain.8 2) The intraventricular MTX / cytarabine treatment of the Bonn protocol requiring an Ommaya reservoir was replaced by intraspinal administration of liposomal cytarabine in view of the expected lower risk of procedure - related infections.

The patient was treated on an acute lymphoblastic leukemia (ALL) protocol for eight cycles of hyperCVAD (cyclophosphamide, vincristine, adriamycin and decadron) alternating with MTX / Ara - C (methotrexate and cytarabine) and achieved complete remission (CR) confirmed by a bone marrow biopsy and by the resolution of most of her skin lesions.

They noted that the addition of cytarabine to the initial regimen may have contributed to the persistence of response after therapy discontinuation, but that remains unclear.

The 28 - day treatment cycle included AZA 75 mg / m2 subcutaneously or intravenously for 7 days per cycle, or cytarabine 20 mg subcutaneously twice daily for 10 days per cycle along with quizartinib at two planned dose levels: 60 mg (dose level 1) or 90 mg orally daily (dose level 2), uninterrupted.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine (AZA) or low - dose cytarabine (LDAC) is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

In AAML 1031, pediatric patients were treated with four - course chemotherapy consisting of two induction courses of cytarabine / daunorubicin / etoposide, a third course of cytarabine / etoposide, and a fourth course of cytarabine / mitoxantrone.

More recently, the monoclonal antibodies inotuzumab and blinatumomab have performed better than cytarabine - based chemotherapy.

AAML 0531 included the same four courses plus a fifth course containing high - dose cytarabine.

«While post-remission chemotherapy with cytarabine has been shown to improve outcomes in AML, the optimal number of courses and cumulative cytarabine exposure is uncertain.»

The study had begun as a comparative study of patients given Gleevec or the previous standard treatment, interferon alfa plus cytarabine.

Researchers at SciLifeLab has together with research physicians at Karolinska University Hospital and scientists at Heidelberg University identified a key player determining response to cytarabine — the most important drug against acute myelogenous leukemia.

Along with high - dose cytarabine and anthracycline, standard - risk patients received an additional two courses of ATO and high - risk patients received an additional three courses of ATO.

It happened while I was undergoing my first round of a chemotherapy — a combination of drugs called R - DHAP (rituximab, dexamethasone, cytarabine and cisplatin).

Vyxeos is made up of daunorubicin and cytarabine — both chemotherapy agents — formulated with the nanomaterial liposome; it was approved for the treatment of acute myeloid leukemia (AML).

He receives chemotherapy (cytarabine) every 8 weeks and prednisone every other day... he is now 6-1/2 years old and stable.

This means steroids in high doses and other drugs such as azathioprine, cytarabine, mycophenolate, cyclosporin, and cyclophosphamide.

CYTOSINE ARABINOSIDE (Cytarabine) Low white blood cell and / or platelet counts - highest risk 7 - 14 days after treatment.