Sentences with phrase «cytogenetic features»

Low risk was defined as patients with the presence of inv (16) / t (16; 16) or t (8; 21) cytogenetic features, NPM1 or CEBPA mutations, or MRD < 0.1 % post-induction I in those with no high - risk features.

Not exact matches

Among patients with favorable cytogenetic and molecular features, the point estimates for disease - free survival and overall survival were approximately 1, indicating no benefit of a fifth course of chemotherapy, Getz said.

However, among patients who had uninformative cytogenetic or molecular features but who were MRD < 0.1 % at the end of induction I, the disease - free survival (HR, 1.86; 95 % CI, 1.18 — 2.92; P =.008) and overall survival (HR, 1.91; 95 % CI, 1.01 — 3.61; P =.046) were almost twice as high in patients who received five treatment courses compared with four courses.

Those with uninformative cytogenetic or molecular markers with negative minimal residual disease at the end of induction were noted to experience the most benefit (nearly 2-fold benefit from receiving a fifth dose of chemotherapy) vs. those with favorable cytogenetic and molecular features who did not experience benefit from receiving a fifth dose of therapy.