Sentences with phrase «cytokine dysregulation»
Several candidate mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.
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IL - 17 is produced mainly by pathogenic ILC3s associated with chronic inflammation and cytokine dysregulation [11] and we did not readily detect IL - 17 in our studies.
The disease is characterized by profound fatigue and disability lasting for at least 6 mo, episodes of cognitive dysfunction, sleep disturbance, autonomic abnormalities, chronic or intermittent pain syndromes, microbiome abnormalities (1), cerebral cytokine dysregulation (2), natural killer cell dysfunction (3), and other symptoms that are made worse by exertion of any kind (4).
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Dysregulation of cytokine signalling is understood to induce autoimmunity.
Cytokines treat infections by turning on various white blood cells, but also cause pain, achiness, fatigue, hormonal dysregulation, and poor sleep.
· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);
Given that low maternal sensitivity and anxiety are interrelated, the association with childhood AD may be similarly mediated by epigenetics or neuroendocrine dysregulation [88, 104, 110], and altered infant cytokine profiles [111].