Sentences with phrase «cytokine expression in»

In 2004 she worked as a trainee at the department of Human Biology, at the University of Maastricht and she performed research on the effects of nutrition on cytokine expression in inflammatory bowel disease.

Dr. Locksley's laboratory focuses on tracking cytokine expression in model systems, as a mechanism to investigate complex functional interactions between innate and adaptive cells in the immune system.

Not exact matches

Outside of the brain, cytokines are released by immune cells fighting infections, and they can alter MHCI expression in a complicated feedback loop.

The researchers concluded that IL - 17A is the dominant cytokine involved in the expression of psoriasis - related genes.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

Tumors exposed to LIGHT showed an influx of T - cells that resulted in rapid and sustained diminishment in size, even after expression of the cytokine stopped.

Studies are in progress to analyze the proinflammatory cytokines gene expression in the NWO syndrome.

We are examining the effect of a maximal exercise stress test on gene expression, metabolism, inflammatory markers, and cytokine levels in ME / CFS patients and healthy controls.

We have also initiated studies of the regulation of cytokine gene expression in these cells.

«We were surprised to see that expression of the gene TSLP — which encodes a cytokine long known to be involved in epithelial - induced inflammation — was exclusive to a particular subset of tuft cells,» Haber noted.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Cytokine expression by human marrow - derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL - 1 alpha.

Cytokine and chemokine expression in the central nervous system associated with protective cell - mediated immunity against Cryptococcus neoformans.

A key transcription factor involved in expression of pro-inflammatory cytokines and senescence is Nuclear factor - kB (NF - kB) 24.

Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF - α: implications for atopic dermatitis.

Co-precipitating of fibrotic lesions as demonstrated by collagen expression in acinar cells may be attributed to defence mechanism against inflammatory cytokine - induced pancreatic injury and inflammation [26]; interestingly, the collagen expression was restored when pancreatic inflammation was relieved [46].

These experiments revealed found that Aβ added to neurons grown in culture increased the expression of collagen VI and that this process involved the immune regulatory cytokine TGFβ.

In par with these studies, the propensity to increase the levels of inflammatory cytokines (IL - 6 and IL - 1β) expression in islets of WNIN / Gr - Ob rats were exacerbated with L - arginine administration in mutantIn par with these studies, the propensity to increase the levels of inflammatory cytokines (IL - 6 and IL - 1β) expression in islets of WNIN / Gr - Ob rats were exacerbated with L - arginine administration in mutantin islets of WNIN / Gr - Ob rats were exacerbated with L - arginine administration in mutantin mutants.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

Further, inactivation of the ABL kinases resulted in decreased expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and cytokine / cytokine receptor pathway signatures (Fig. 6B).

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

[53] We have also demonstrated similar effects of GHRH antagonists on in vivo cytokine gene expression by HCC1806 and MX - 1 triple negative human breast cancer.

We have recently reported that the GHRH antagonist, MIA - 602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.

The successful candidate will receive extensive training on proteomics - based discovery (secretome proteomics to identify cytokines important in different children's cancers, protein expression profiling of subcellular fractions and organelles, and interactome proteomics to identify novel protein — protein interactions) and follow - up of proteomic findings (molecular cell biological characterization of protein functions and signaling).

In addition, LA promoted inflammatory processes activating the nuclear factor - κB transcription factor as well as stimulating the expression of cyclooxygenase - 2 and pro-inflammatory cytokines.

Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q - real - time PCR; immune response by in - vitro antigen - specific T - cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis.

Citing again from the study previously mentioned titled Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll - Like Receptor - 4 and Suppressor of Cytokine Signaling - 3 «Thus, saturated fats may have a more profound role in the pathogenesis of postprandial inflammation, as they may also perpetuate inflammation through the increases in LPS and TLR - 4.»

Mentula P, Kylanpaa ML, Kemppainen E, Jansson SE, Sarna S, Puolakkainen P, Haapiainen R, Repo H.Plasma anti-infl ammatory cytokines and monocyte human leucocyte antigen - DR expression in patients with acute pancreatitis.

Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies.

Molecular studies have also suggested that ARD is associated with increases in pro-inflammatory cytokine mRNA expression yet without histologic evidence of inflammation.

These findings are also in line with other studies that have shown that chronic caregiver stress in the postpartum and early childhood period has been associated with persistent wheeze in early childhood4 as well as factors that may initiate or potentiate inflammation in the lung (eg, IgE expression, enhanced nonspecific and allergen - specific lymphocyte proliferation, differential cytokine expression).5, 7 Both persistent wheeze and atopy have been linked to reduced lung function in childhood.49 This cumulative stress model is particularly relevant given that maternal IPV may become a more direct stressor for toddlers who are witnessing violence against their mothers.50