Sentences with phrase «cytokine production as»

To separate the effects of the short - term stress of a marital conflict from the long - term strains of marital discord on local and systemic proinflammatory cytokine production as well as wound healing, couples were recruited for two 24 - hour admissions to our General Clinical Research Center (GCRC).

This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as well as altered chemotaxis responses, decreased phagocytosis and antigen presentation capacity.

Not exact matches

Some amount of inflammation is generally beneficial, as it ramps up production of cytokines, proteins that help us heal and protect us from the effects of overexertion.

Although it has been suggested that resveratrol has anti-inflammatory properties, in this study resveratrol did not suppress autoimmune responses as measured by levels of MOG35 -55-specific lymphoproliferative responses and pro-inflammatory cytokine production.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Interleukin 17 is a cytokine that acts as a potent mediator in delayed - type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma.

Remarkably, recent studies from several laboratories including Dr. Kim's lab identified Nurr1 as a key modulator of (neuro) inflammation functioning as a transcriptional repressor for neurotoxic cytokine production.

The cell assays are based on blood samples or tissue biopsies from these patients, and readouts are either specific, such as antibody production or the production of proinflammatory cytokines, or wider, such as proteomic effects of the probes.

As a person ages, the immune response to antigenic stimulation with the influenza virus shifts toward T helper type 2 cytokine production.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

What's more, consuming refined starches and sugar may boost the production of proinflammatory molecules known as cytokines.

On the other hand, elder increases the production non-inflammatory infection - fighting cytokines as much as 10 fold.

As an antioxidant, it inhibits the production of proinflammatory cytokines (signaling molecules).

The detrimental effects of omega - 6s are articulated by Fernandes and Venkatraman (1993), with, «The increased consumption of many vegetable oils particularly of the n - 6 series is... viewed as pro-inflammatory and is suspected as one of the possible causes for the rise in certain malignant tumors, rheumatoid arthritis and autoimmune diseases primarily due to the increased production of pro-inflammatory cytokines» (p. S19).

The high antioxidant content of blueberries contributes many health benefits, such as boosting the production of cytokines, which are small proteins that interact with other cells and help regulate immune responses, promote anti-inflammatory activity, and strengthen cell membranes, among other important functions.

Proteolytic enzymes such as papain, bromelain, trypsin and chymotrypsin promote healing by supporting the production of cytokines, activating immune system proteins such as alpha -2-macroglobulins, breaking down fibrinogen and slowing the clotting mechanism (30).

A lack of efforts to reduce inflammation in the body can contribute chronic Western disease, such as heart disease and cancer Omega - 3 fatty acids have proven to reduce the production of molecules and substances linked to inflammation, such as inflammatory eicosanoids and cytokines Studies have consistently shown a link between higher omega - 3 intake and reduced inflammation.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

In certain types of cancer, erythropoietin production by the kidneys, as well as its activity on the bone marrow, is inhibited by cancer - produced cytokines (the substances that mediate inflammation) as well as by chemotherapeutic drugs.

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

Thus, a series of studies have shown that marital conflict alters physiological functioning, and hostile behavior, particularly during conflict, markedly enhances adverse physiological changes; moreover, women appear to be more adversely affected than men.5 In this study, we extended this line of research to assess how hostile marital behavior modulated an important health outcome, wound healing, as well as local and systemic proinflammatory cytokine production.

Objective To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.

As expected, cytokine production in blister chamber fluid increased over time at both GCRC admissions (Figure 2).