Sentences with phrase «cytokine production by»

A Herxheimer Die - off reaction is the result of a cytokine flare (increased cytokine production by the immune system) in response to antibiotics killing germs.

A Herxheimer Die - off reaction is the result of a cytokine flare (increased cytokine production by the immune system) in response to antibiotics killing Lyme germs.

Not exact matches

When cells that produced IL - 21 were put in culture with synovial fibroblasts (which are the main contributors to joint inflammation in rheumatoid arthritis), they induced the production of proinflammatory cytokines by these synovial fibroblasts, and cells that do not produce IL - 21, did not demonstrate this same outcome.

The third approach turns up production of T regulatory cells, which prevent specific immune cells from copying themselves and can also suppress rejection by secreting biochemicals called cytokines that direct the immune orchestra to change its tune.

Dr. Wang plans to continue studying the effects of TNF and IL - 17 on melanocytes, and would like to expand the research to 3D skin models — fabricated samples of tissue in vitro that behave like human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.

The research suggests that a cytokine produced by inflammatory cells near a prostate tumor induces cancer cells to decrease production of a protein that blocks metastasis.

Although it has been suggested that resveratrol has anti-inflammatory properties, in this study resveratrol did not suppress autoimmune responses as measured by levels of MOG35 -55-specific lymphoproliferative responses and pro-inflammatory cytokine production.

The Human Functional Genomics Project, run by professors Mihai Netea and Leo Joosten at Radboud university medical center, UMCG Professor Cisca Wijmenga and Professor Ramnik Xavier at the Broad Institute of MIT and Harvard investigated how differences in cytokine production during a Borrelia infection in 500 healthy volunteers can be explained.

The variation in immune response can be largely explained by differences in the production of cytokines, the most important signalling molecules in our immune system.

This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as well as altered chemotaxis responses, decreased phagocytosis and antigen presentation capacity.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

Protein secretion does not always mirror mRNA levels and most workers in the field would adopt a more conservative profile of cytokine and growth factor production by MSC.

Interleukin 17 is a cytokine that acts as a potent mediator in delayed - type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma.

Severity of AP has been predicted by the magnitude of local and systemic inflammatory cytokine production [33] and several reports have well documented for over activation of leukocytes being the major contributor of inflammation leading to multiple organ dysfunction syndrome [34].

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

A major aspect of this process is the production of multiple angiogenic cytokines and growth factors in response to hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (hypoxia - inducible factor 1).

The Raf ‐ 1 kinase inhibitor protein participates in the pathogenesis of IL ‐ 17 ‐ mediated autoimmune diseases and inflammation by promoting the formation of the IL ‐ 17RA ‐ Act1 complex, required for downstream signaling and cytokine production.

He showed that engagement of PD - 1 by PD - L1 or PD - L2 inhibited T cell activation, cytokine production, and cytolytic activity whereas blockade enhanced these activities.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

Viral disease in Ifitm3 - / - mice was accompanied by elevated production of cytokines, most notably IL - 6.

(2005) Pressure - Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated by Calcium Channels in Retinal Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).

And according to recent studies conducted in Japan, the full ripe bananas with dark patches on their skin produce the largest quantity of TNF (Tumor Necrosis Factor), a cytokine that fights abnormal tumor cells in the body by stimulating the production of white blood cells and assisting their communication.

The detrimental effects of omega - 6s are articulated by Fernandes and Venkatraman (1993), with, «The increased consumption of many vegetable oils particularly of the n - 6 series is... viewed as pro-inflammatory and is suspected as one of the possible causes for the rise in certain malignant tumors, rheumatoid arthritis and autoimmune diseases primarily due to the increased production of pro-inflammatory cytokines» (p. S19).

It does this by boosting the production of cytokines, a type of protein that is released to fight specific antigens, generating a protective immune response.

In times of intense physical stress, they help enhance immune activity by promoting the production of cytokines.

It has also been found to reduce the production of proinflammatory cytokines, an effect that may be mediated by its antioxidant content.

Im general, Glutamine is utilised at a high rate by cells of the immune system in culture and is required to support optimal lymphocyte proliferation and production of cytokines by lymphocytes and macrophages1.

Phytochemicals called anthocyanins give the vegetable its color and enhance wound healing by boosting production of cytokines, a type of protein that triggers a protective immune response.

Proteolytic enzymes such as papain, bromelain, trypsin and chymotrypsin promote healing by supporting the production of cytokines, activating immune system proteins such as alpha -2-macroglobulins, breaking down fibrinogen and slowing the clotting mechanism (30).

Impaired medullary circulation and direct toxicity due to a drug metabolite seem to play a critical role in inducing interstitial fibrosis, which can be facilitated by a sustained production of some growth factors and cytokines.

Our study suggests that B. fragilis is able to ameliorate leaky gut by directly targeting tight junction expression, cytokine production and / or microbiome composition.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

At the Bundesforschungsanstalt research center in Karlsruhe, Germany, scientists conducting studies on Elderberry showed that elderberry anthocyanins enhanced immune function by boosting the production of cytokines.

In certain types of cancer, erythropoietin production by the kidneys, as well as its activity on the bone marrow, is inhibited by cancer - produced cytokines (the substances that mediate inflammation) as well as by chemotherapeutic drugs.

The substantial increases in local cytokine production over time (Figure 2) have been assumed to be primarily a function of their local synthesis at the site by the cells that are migrating to the chamber.22, 58 In our data, correlations between cell numbers and cytokine levels at 22 hours after the social support interaction were r = 0.29 and P <.01 for IL - 6; r = 0.08 and P =.45 for TNF - α; and r = 0.13 for IL - 1β and after the conflict interaction, r = 0.52 and P <.001 for IL - 6 and r = 0.38 and P <.001 for both TNF - α and IL - 1β.