Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential
cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.
Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and
cytokine receptor expression and a key regulator of early activation and proliferation in T cells.
Not exact matches
Patients with depression exhibit the main features of an inflammatory response, including increased
expression of
cytokines and their
receptors.
The retinoic acid
receptor - α modulators ATRA and Ro415253 reciprocally regulate human IL - 5 + Th2 cell proliferation and
cytokine expression.
We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased
expression of genes in the JAK / STAT and
cytokine /
cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA
expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.
Further, inactivation of the ABL kinases resulted in decreased
expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and
cytokine /
cytokine receptor pathway signatures (Fig. 6B).
Proinflammatory
cytokines enhance estrogen - dependent
expression of the multidrug transporter gene ABCG2 through estrogen
receptor and NF -LCB- kappa -RCB- B cooperativity at adjacent response elements.
«Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the
expression of Toll - like
receptor - 4 and suppressor of
cytokine signaling - 3.»
Citing again from the study previously mentioned titled Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the
Expression of Toll - Like
Receptor - 4 and Suppressor of
Cytokine Signaling - 3 «Thus, saturated fats may have a more profound role in the pathogenesis of postprandial inflammation, as they may also perpetuate inflammation through the increases in LPS and TLR - 4.»
The
expression of Toll - like
receptors (TLRs),
cytokine and chemokine responses were measured by real time PCR.