Sentences with phrase «cytokine release»

CAR - T, though, is also associated with severe and potentially deadly side effects, including lethal instances of cytokine release syndrome with some patients dying from brain swelling in separate studies from the Novartis drug.

After receiving the engineered cells, she experienced no fevers or other signs of cytokine release syndrome (CRS), a condition that has been observed in other patients undergoing CTL019.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

Four of the eight children experienced cytokine release syndrome.

But while the technology itself is undeniably exciting, some companies, like Juno Therapeutics, have been struggling with the reality of dangerous side effects including cytokine release syndrome and brain swelling during trials.

The pathogenesis of AD is known to involve abnormal levels of specific cytokines released by T - helper 2 cells detected in cord blood or infant peripheral blood [117 — 120].

She battled what is known as cytokine release syndrome and neurological side effects, both common to CAR T - cell therapy, but quickly recovered.

CAR - T approaches involve reengineering T - cells to find and destroy cancer cells, but that process can cause cytokine release syndrome (CRS), a life - threatening immune response NantKwest hopes to sidestep.

All 10 patients who received the CTL119 cells experienced mild cytokine release syndrome (CRS), a known potentially lethal type of toxicity, within a few days after receiving their infusions; however, none required treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis.

Using in vitro models of bacterial: gastric epithelial cell interactions, we have shown that cag island genes are required for pro-inflammatory cytokine release and induction of apoptosis, and that these events are mediated by activation of NF - kB and / or mitogen - activated protein kinases (MAPK).

In ZUMA - 1, 12 % of the patients had a grade 3 or higher cytokine release syndrome and that is essentially a patient requiring mechanical ventilation or needing treatment with a high - dose vasopressor.

Unfortunately, those patients may be unlikely to make it through the 17 days we need to manufacture the CAR T cells, and it is less likely that they will be able to tolerate the severe cytokine release syndrome or get through the other acute toxicities of therapy.

Statin drugs block the inflammatory cytokine release in the post operative patient, thus reducing mortality from the procedure.

Toxicity is a significant concern with CAR T - cell therapies, since they have the capacity to elicit not only expected serious adverse events but also unexpected ones, including cytokine release syndrome (CRS), neurologic toxicity, «on target / off tumor» recognition, and anaphylaxis.

Building on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released by immune cells involved in fighting the infection.

More than half (58 %) of treated patients in JULIET experienced cytokine release syndrome, which was a grade 3/4 event in about one - quarter of the patients.

One patient had a myocardial infarction while suffering from cytokine release syndrome.

[17] Wheat germ agglutinin is the most studied lectin with proinflammatory responses causing histamine secretions, cytokine release of interleukin responses and inflammatory reactions, leading to leaky gut or increased epithelial cell permeability.

In normal immune responses, a second type of helper cells, known as TH2, secrete another batch of cytokines, including one called interleukin - 4 (IL - 4) that turns off the cytokine release from TH1 cells.

«T - cell receptor therapy achieves encouraging clinical responses in multiple myeloma: NY - ESO T cell receptor therapy found to be safe, with no cytokine release syndrome cases.»

What's more, none of the patients experienced macrophage activate syndrome or cytokine release syndrome, an infusion reaction observed in other gene therapy trials characterized by fever, nausea, chills, hypotension or a rash.

All patients who received the CTL019 «hunter» cells experienced a cytokine release syndrome (CRS) within a few days after receiving their infusions — a key indicator that the engineered cells have begun proliferating and killing tumor cells in the body.

All six had cytokine release syndrome (CRS), from which they recovered after treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

Cytokine release syndrome occurs when many cytokines get released into the serum upon CAR T - cell injection; patients can get high fevers and sometimes hypertension, and occasionally there is a need for mechanical ventilation or administration of vasopressors, but that is rare.

The two toxicities that we primarily see related to CAR T cells are cytokine release syndrome and CAR T - cell — related encephalopathy or neurologic events.

This cytokine release can affect ECL cells by impairing their secretory function and lead to achlorhydria and subsequently gastric cancer via ECL hyperplasia by increased gastrin stimulation.

The general ill health (cachexia) that malignant tumors and may other serious health issues cause can lower blood cholesterol levels in a variety of ways (cytokine release, poor appetite, etc.).