Henrik Bringmann (Howard, MPG)-- «Experiments concerning the mechanism
of cytokinesis in Caenorhabditis elegans embryos» (2007)
Thus, although NMHC II - A can substitute for NMHC II - B to maintain integrity of the spinal canal, NMHC II - B plays an isoform - specific role
during cytokinesis in cardiac myocytes and in migration of the facial and pontine neurons.
We propose that these microtubular structures contribute to a checkpoint control that retains the equatorial position of the ring when progression
through cytokinesis is delayed.
Yeast cytokinesis occurs at the microcompartment of the bud neck and involves the controlled synthesis of cell wall components.
The assembly and stability of FtsZ protofilaments have been shown to play critical roles in
bacterial cytokinesis.
Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to
cause cytokinesis defects.
Skop studies cell diversification, which begins
with cytokinesis, the division of cells in an embryo.
Rancanti et al. found that aneuploidy facilitated adaptive evolution in yeast cells lacking the conserved motor protein Myo1 involved in cytokinesis [12].
Naomi Foster (Gonzalez, MPG)-- «The involvement of ARF6 in rapid membrane recycling during Drosophila
spermatocyte cytokinesis» (2006)
Similar to B -LRB--) / B -LRB--) mice, most B (a *) / B (a *) mice died late in embryonic development with structural cardiac defects and
impaired cytokinesis of the cardiac myocytes.
Note that the cell progresses into mitosis, which ends with a double - nuclei cell following
failed cytokinesis.
The project will first focus on the sensors of the cell wall integrity (CWI) signal transduction pathway and their relation to the control of the spatial and temporal organization of protein complexes and regulatory components during
yeast cytokinesis.
We found that curcumin induced filamentation in the Bacillus subtilis 168, suggesting that it inhibits
bacterial cytokinesis.
This skill has given her the confidence to tackle «complicated, far - out» experiments, like her doctoral research that uncovered the role that secretion plays in
cytokinesis, which she did in White's lab, and her investigation of the midbody during her postdoc.
Genetic screens, epistasis analyses and site - directed mutageneses with the main CWI sensors (Wsc1, Wsc2 and Mid2) and
the cytokinesis regulator Inn1 will be used to identify new components involved in the regulatory networks in vivo.
Such functions include the stabilization of replication forks and the regulation of
cytokinesis.
How the vital processes of cell cycle control (with the final event of
cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.
For example, the shapes of cells during cell division (
cytokinesis) are linearly related to mechanical moduli of cellular cortex across many cytoskeletal mutants.