Sentences with phrase «cytolytic cd8»

Allergic (hypersensitivity) and immune - mediated reactions: Type 1 (acute anaphylaxis): angiodema (especially the head), anaphylaxis (shock) and death; Type 2 (cytolytic): immune - mediated hemolytic anemia, immune - mediated thrombocytopenia (suspected only; causality has not been confirmed); Type 3 (immune - complex): cutaneous ischemic vasculopathy associated with rabies vaccine, corneal edema («blue - eye») associated with CAV - 1 vaccine, immune - mediated disease.

Alpha Herpesviruses such as FHV - 1 cause disease by two distinctly different mechanisms: 1) cytolytic (cell - rupturing) disease which involves active viral replication and destroys the epithelial cells of the cornea and conjunctiva causing ulceration; and, 2) immune - mediated disease results from the deposition of viral antigen in subepithelial tissues.

T11 / CD2 activation of cloned human natural killer cells results in increased conjugate formation and exocytosis of cytolytic granules.

It sounds scary, cytolytic vaginosis, but it really isn't.

Only a yeast infection will present with a positive swab for candida, if you have cytolytic vaginosis the candida swab will be negative.

If you're suffering from the symptoms of a yeast infection but the vaginal swab comes back negative, you should suspect cytolytic vaginosis.

Neither a yeast infection nor cytolytic vaginosis are sexually transmitted, meaning you don't typically «catch» them from your partner, however sex can lead to imbalance in the vaginal and penile flora so both partners (same sex or opposite sex) can develop similar symptoms.

A yeast infection (candidiasis) is fungal overgrowth, but cytolytic vaginosis is bacterial overgrowth.

The TCGA analysis showed tumors with PTEN loss in the background of BRCA1 / 2 deficiency had lower levels of cytolytic immune molecules and immune - activating pathways that would normally drive immune responses against tumors.

Profound Metabolic, Functional and Cytolytic Differences Characterize HIV - Specific CD8 T Cells in Primary and Chronic HIV Infection.

These results indicate that Ly49 expression is associated with a differentiation program of cytolytic CD8 + T cells triggered upon chronic antigenic exposure.

He showed that engagement of PD - 1 by PD - L1 or PD - L2 inhibited T cell activation, cytokine production, and cytolytic activity whereas blockade enhanced these activities.

In addition, we observed that donor T cells recovered from VPA - treated BMT recipients and controls on day 14 showed comparable cytolytic activity against host - type leukemia cells (Fig. 5F).

We report here that, despite their phenotypic and cytolytic similarities, Ly49 + CD8 + T cells and conventional Ly49 - CD44high memory - phenotype CD8 + T cells present strikingly distinct features.

In addition, the CD8 subset primarily function as cytolytic killers for clearing pathogen - infected cells or for targeting tumors.

In this model, FHL is triggered by the lymphocytic choriomeningitis virus (LCMV), a virus that would normally be cleared by the CD8 T cell cytolytic response in perforin - sufficient mice.

Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.

Cutting edge: differential segregation of the SRC homology 2 - containing protein tyrosine phosphatase - 1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions.

Effect of CD4 + CD25 + and CD4 + CD25 - T regulatory cells on the generation of cytolytic T cell response to a self but human tumor - associated epitope in vitro.

A family of serine esterases in lytic granules of cytolytic T lymphocytes.

Analysis of variant - specific antigens by selection of antigen - loss variants with cytolytic T cell clones.

A p16INK4a - insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA - A2 melanomas.

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

Gaugler B, Van den Eynde B, van der Bruggen P, Romero P, Gaforio JJ, De Plaen E, Lethé B, Brasseur F, Boon T. Human gene MAGE - 3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

Clonal analysis of the syngeneic cytolytic T lympocyte response.

Improved proliferation of antigen - specific cytolytic T lymphocytes using a multimodal nanovaccine.

Traversari C, van der Bruggen P, Van den Eynde B, Hainaut P, Lemoine C, Ohta N, Old L J, Boon T. Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes.

[i] Romero P, Dunbar PR, Valmori D, Pittet M, Ogg GS, Rimoldi D, Chen JL, Lienard D, Cerottini JC, Cerundolo V. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen - experienced tumor - specific cytolytic T lymphocytes.

(PMID: 7927540)[ii] Boël P, Wildmann C, Sensi M - L, Brasseur R, Renauld J - C, Coulie P, Boon T, van der Bruggen P. BAGE, a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergin MT, Ozols J, Meehan J, Mauri F. Induction of antigen - specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide - pulsed autologous antigen presenting cells.

Analysis of antigens recognized on human melanoma cells by A2 - restricted cytolytic T lymphocytes (CTL).

These fCD8 + cells have cytolytic potential and can be redirected to target and kill HIV - infected cells using bispecific antibodies.