Not exact matches
Scientists have discovered a key molecule linked to Human
Cytomegalovirus (HCMV)
infection, which is harmless for healthy people but can cause miscarriage and birth defects
during pregnancy.
The study may explain, among other things, how the mother's
infection with the
cytomegalovirus (CMV)
during pregnancy, which affects her own and her fetus's immune system, increases the risk that her offspring will develop autism or schizophrenia, sometimes years later.
The researchers sought to explore the link between maternal
infection and risk for autism, focusing on five pathogens known collectively as ToRCH agents — Toxoplasma gondii, rubella virus,
cytomegalovirus, and herpes simplex viruses type 1 and 2 — to which exposure
during pregnancy can lead to miscarriage and birth defects.
Lastly, increased systemic inflammation seen
during ageing is also apparent in chronic
infections such HIV or
cytomegalovirus, 10,15 obesity7 and individuals enduring chronic psychological stress.16 Similarly, the main features of immunosenescence are apparent in many of these conditions, including decreased antibody responses, increased
infections, malignancies and also incidences of inflammatory associated disorders such as cardiovascular disease.7, 10,15,16 Inflammation and premature immunosenescence are, therefore, prevalent features of many common conditions of modern life, such as obesity and stress, and could have negative health consequences for large proportions of society well before old age is reached.