Curcumin exerts both direct and indirect antioxidant effects by scavenging reactive oxygen species (ROS)(38) and inducing the expression
of cytoprotective proteins in an Nrf2 - dependent way (39).
Further they found that although hepatitis C virus (HCV) and alcohol independently activated FOXO3, in combination they suppressed FOXO3, reduced expression of
cytoprotective genes, and worsened liver injury.
They began by saying «in recent years, evidence has mounted in favour of the anti-inflammatory, immunomodulatory and
cytoprotective effects of the simplest amino acid L - glycine».
However, it is unclear why these highly conserved,
cytoprotective quality control mechanisms fail to function effectively with age or in age - related diseases.
GS Immuno Zinc is an advanced
gastric cytoprotective formula designed to support and maintain the integrity of the protective mucosal lining.
What has been gleaned from scientific literature is that certain phytochemicals, such as the triterpenes that cucumber contains, may offer
important cytoprotective capabilities, among other benefits, that may preserve cutaneous barrier function and cellular immunity (9, 10).
The plasma lifetimes of some important «nutraceuticals» like sulforaphane (cruciferous vegetables) or epigallocatechin gallate (green tea) are around 4 - 8 hours, but once they've activated transcription factors, levels of
cytoprotective genes can remain elevated for days.
Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum - 2006 International Journal of Molecular Medicine.
The role of FOXO in injury processes is complex as FOXO transcription programs can either be
cytoprotective or cytotoxic, and well - documented examples of both phenomena are numerous,» says Steven A. Weinman, MD, PhD, Department of Internal Medicine at the University of Kansas Medical Center.
Nrf2 binds to antioxidant response elements (AREs) found in the promoters of over 200 anti-oxidant and
cytoprotective genes including NAD (P) H dehydrogenase, quinone 1 (NQO1), catalase (CAT), glutamate - cysteine ligase (GCLC), aldoketoreductase family members, thioredoxin reductase (TXNRD1), and heme oxygenase - 1 (HMOX1)[12].
University of Ottawa Faculty of Medicine
The cytoprotective NAIP and XIAP genes: identification of activation pathways and inducing agents
Using a mutant diabetes prone NOD mice lacking Vanin - 1, we showed that cysteamine exerts
a cytoprotective role on pancreatic islets and thus Vanin - 1 deficiency is detrimental in type 1 diabetes.
The polysaccharides, or polymeric carbohydrate molecules within pumpkin, elicit significant antioxidant and
cytoprotective effects, such that pumpkin may aid in ameliorating some of the oxidative stress and inflammation behind most chronic and degenerative diseases (Song et al., 2013).