Sentences with phrase «cytosine at»

The best - known example of this kind of change is a methylation of the base cytosine at the 5th position on its carbon ring (5mC).

Not exact matches

One problem is that although the technique is great at distinguishing adenine from methyladenine, it doesn't quite reach single - base resolution for cytosine and methylcytosine.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

The team looked at methylation, in which a methyl group is placed onto cytosine in DNA sequences.

Previous work had shown that two variations in the COX - 2 gene, with either a guanine (G) or a cytosine (C) molecule at a particular spot in the gene's DNA sequence, lead to different levels of COX - 2 protein.

The DNMT3A structure that Song's team cracked explains why mammalian DNA methylation predominantly occurs at «CpG dinucleotides» — DNA locations where cytosine nucleotides are next to guanidine nucleotides.

Transformed cells such as the Jurkat line may show aberrant DNA methylation patterns at specific loci [57], possibly complicating analyses of cytosine methylation and HIV - 1 latency.

Based on the nucleotide context, the authors suggest that a new mutational mechanism may be at work involving cytosine deamination of single - stranded DNA (presumably during replication).

In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.

The recovered DNA sequences exhibited signatures of postmortem DNA damage typical of ancient DNA, with preferential fragmentation at purines and inflated rates of cytosine deamination at single - stranded overhangs (19, 20).