Sentences with phrase «cytosine deamination»
The recovered DNA sequences exhibited signatures of postmortem DNA damage typical of ancient DNA, with preferential fragmentation at purines and inflated rates of cytosine deamination at single - stranded overhangs (19, 20).
http://www.pnas.org/
Cytosine deamination rates and fragmentation patterns were plotted using mapDamage2.0 (70), based on 100,000 randomly selected alignments against EquCab2.0.
Chief among these telltale DNA alteration patterns is cytosine deamination, in which cytosine (C) bases are replaced with uracil (U), a base that normally occurs in RNA.
Based on the nucleotide context, the authors suggest that a new mutational mechanism may be at work involving cytosine deamination of single - stranded DNA (presumably during replication).
Not exact matches
The SureSeq mix increases the success and accuracy of hybridization - based NGS for FFPE samples by repairing damage such as nicks and gaps, oxidized bases, blocked 3» ends, and deamination of cytosine to uracil.