"Cytoskeletal" refers to the structure or framework inside a cell that gives it shape, support, and helps it carry out its functions. It is like the skeleton of the cell that provides strength and allows movement.
Full definition
In particular, these characteristics determine how easily it can push against a cytoplasm's surrounding water and move through its ever - changing web
of cytoskeletal protein structures.
Our labs study the movement of individual cells that crawl through complex environments, and we try to understand how these cellular movements are linked to the creation and growth of
cytoskeletal protein networks inside the cells.
In addition, breast cancer cells respond differently to S1P in terms of the regulation of actin
cytoskeletal structures.
The consortium is awarded a 5 year grant for studying the evolution of
cytoskeletal elements by the Wellcome Trust.
«Twin expression profiling identifies
cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis»
Are there defects in
cytoskeletal organization in toddler mutant mesendoderm, which might affect cell division and cell numbers as well as cell migration?
The rapid onset of the freezing phenotype led to the hypothesis that Mcf1 may be acting on a pre-existing eukaryotic molecular switch governing actin
cytoskeletal dynamics such as the rho GTPases.
Jonathan Boulais and Jean - François Côté of the IRCM
Cytoskeletal Organization and Cell Migration Research Unit, Jordan Pinder and Graham Dellaire of Dalhousie University, Daria Frank and Cyrus Khandanpour of the University Hospital of Essen, Josée Hébert and Elliot Drobetsky of the Centre de recherche de l'Hôpital Maisonneuve - Rosemont, and Stéphane Richard and Alexandre Orthwein of the Jewish General Hospital's Lady Davis Institute for Medical Research, also collaborated on the study.
His group's paper in the Journal of Physics A: Mathematical and Theoretical describes a new theoretical approach to study the effect of intermolecular interactions on the dynamics of motor proteins that move
along cytoskeletal filaments known as microtubules.
This discovery begs the question of how these ancestral proteins operate and whether understanding their function can yield new insight into the evolution of eukaryote cells and the transition of
cytoskeletal machinery from archaea to eukaryotes.
They attach themselves to large cargoes like mitochondria or chromosomes and pull them along
cytoskeletal filaments to the far reaches of a cell.
The archaeal host, with a large complement of
cytoskeletal genes and regulatory GTPases, was probably capable of complex shape regulation.
Collectively, our results indicated that RASSF1 acts to restrict EMT and invasion by indirectly controlling YAP nuclear shuttling and activation through a RhoB -
regulated cytoskeletal remodeling process, with potential implications to delay the progression of RASSF1 - hypermethylated lung tumors.
The team found changes in a gene encoding a previously unknown «dynein,» a protein that moves like a railroad locomotive along
cytoskeletal fibers called microtubules, hauling other molecules as cargo.
Ideally, this would involve highly - fluorescent molecules that can
bind cytoskeletal proteins with high specificity without being toxic to the cell.
O - GlcNAc not only plays a key role in signaling, in transcription and in
cytoskeletal functions, but it also underlies glucose toxicity in diabetes, is important in neurodegenerative diseases and is important in cancer etiology.
My aim is to find
Archaeal cytoskeletal proteins and identify their structure using spinning disk confocal microscopy.
Aidinis V. Carninci P., Armaka M., Witke W., Harokopos V., Pavelka N., Koczan D., Argyropoulos C., Thwin M., Möller S., Gopalakrishnakone P., Ricciardi - Castagnoli P., Thiesen H.J., Hayashizaki Y. and Kollias G.,, 2005, «Twin expression profiling
identifies cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis», PLoS Genetics, (Vol 1 (4), e48 [PubMed].
Specifically, the aims of recent projects were to determine whether
axonal cytoskeletal disruption, transport abnormalities, and electrophysiological dysfunction occur prior to RGC death in experimental glaucoma (rodent and non-human primate models) and whether some of these phenomena are detectable by clinically - applicable means.
The resolution of current imaging techniques is insufficient to discern whether individual axons are dropping from bundles without bundle collapse (thus manifesting as reduced birefringence without bundle thinning) or whether
cytoskeletal disruption occurs within axons that otherwise remain present within bundles.
Asymmetric RNA localisation can be achieved by different mechanisms, such as active transport of RNAs by motor proteins moving
on cytoskeletal elements, local protection of RNAs from degradation, facilitated diffusion and trapping.
As Guo explains it, «the faster you move, the more permanent
[cytoskeletal] structures you would see and feel resistance to.»
«If you ask a nucleus, they would tell you the cytoplasm is like honey, because they are really large and slow, and they don't
feel cytoskeletal structures — they only feel the viscous disassembled protein solution, and have very small resistance,» Guo says.
Actin is a filamentous protein, which together with
other cytoskeletal elements forms a dynamic network of filaments that provide both structural support, as well as critical functional capabilities, to the cell.
Research suggests that very scarce chemical cues can trigger physical changes in the cell, including remodeling the plasma membrane and
recruiting cytoskeletal machinery, to transform the dichty from a fat, happy cell to an elongated cell with a distinct front and rear end, ready to migrate.
The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins,
including cytoskeletal elements and signaling proteins.
Their observation provides a better understanding of
cytoskeletal self - organization in general, which may in turn lead to better drug design and new materials that can mimic cellular behaviors.
The
main cytoskeletal structure in adult hydra is an array of aligned fibers that span the entire organism.
Hydras are much simpler than most of their cousins in the animal kingdom, but the basic pattern of
aligned cytoskeletal fibers is common in many organs, including human muscles, heart, and guts.
The stretch induced changes in proteins related, e.g., to
certain cytoskeletal proteins, but also in enzymes associated with protein synthesis, such as eukaryotic elongation factors 1 - beta and 1 - delta.
Soroka, C.J., Chew, C.S., Modlin, I.M., Hanzel, D., Smolka, A. and GOLDENRING, J.R. Characterization of membrane and
cytoskeletal compartments in cultured parietal cells using immunofluoresence and confocal microscopy.
The cells made more proteins involved in mRNA translation, which was followed by production of
more cytoskeletal proteins.
Inhibitory signaling blocks activating receptor clustering and induces
cytoskeletal retraction in natural killer cells.
For example, the shapes of cells during cell division (cytokinesis) are linearly related to mechanical moduli of cellular cortex across
many cytoskeletal mutants.
Detailed investigations demonstrated that the formation of stress fibers and cell - cell junctions created the force necessary for the condensation process, all mediated by MSCs through the
actomyosin cytoskeletal axis.
Phrases with «cytoskeletal»