O - GlcNAc not only plays a key role in signaling, in transcription and in
cytoskeletal functions, but it also underlies glucose toxicity in diabetes, is important in neurodegenerative diseases and is important in cancer etiology.
Regulation of cellular proliferation,
cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.
Activated ERK1 / 2 modulates the
functions of several transcription factors, protein kinases, protein phosphatases,
cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the
function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].