The team found changes in a
gene encoding a previously unknown «dynein,» a protein that moves like a railroad locomotive along
cytoskeletal fibers called microtubules, hauling other molecules as cargo.
Many of the downregulated
genes are smooth muscle
cytoskeletal elements, including TCAP (titin - cap), TPN1 (tropomyosin), DMD (dystrophin), SMTN (smoothelin), TAGLN (transgelin), MYH11 (smooth muscle myosin heavy chain 11), and CNN1 (smooth muscle calponin 1).