Sentences with word «cytostatic»

The treatment of cancer often involves different forms of cytostatic drugs as well as surgery and radiotherapy.

Divalent gold complex isolated for the first time in a pure form / New fundamental insight also provides possible explanation of the mechanism of action of cytostatic gold (+ III) porphyrins...

In the present experimental study, the researchers have sought means of inhibiting the DNA - repair enzyme MGMT (O6 - methylguanine - DNA - methyltransferase), which plays a key part in cytostatic resistance.

Pharmacy technician, 2014, 2016, Oncology Hospital, Bialystok, Podlaskie, Poland, Assistence for Registered Pharmacist in cytostatic drug preparation.

Flavopiridol should exert cytostatic activity because of the pivotal role of the cdks in the cell division cycle.

Blocking Wingless / beta - catenin also inhibits the MGMT enzyme, which in turn prevents cytostatic resistance.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation.

Further, at a low cytostatic concentration (2 nM), ActD causes ribosomal stress leading to a decrease in HDM2 activity and thereby p53 stabilization and activation.

A low, non-genotoxic, dose (about 1 nM) of ActD has been shown to induce a reversible cytostatic effect in normal proliferating dermal fibroblasts and protect them from the aneuploidy induced by the aurora kinase inhibitor VX - 680 and the toxic effects of gemcitabine [46, 47].

ActD has been shown to have a reversible cytostatic effect and the ability to arrest cells in both the G1 and G2 phase of the cell cycle [17].

Researchers at Karolinska Institutet in Sweden have found a new way of preventing resistance to cytostatics used in the treatment of cancers such as medulloblastoma, the most common form of malignant brain tumour in children.

«The rate of tumor necrosis due to 3BP treatment seems to exceed all known cytostatic drugs,» they wrote.

Results Although doctors had pumped the subjects» bodies full of cell - killing cytostatic drugs and exposed them to radioactive radiation, these people became fitter and stronger.

It has long been known that antibiotics suppress various immune functions, and especially macrophage activities such as chemiluminescence response, chemotactic motility, bactericidal and cytostatic ability and similar negative effects have also been seen with other commonly used drugs such as H2 - blockers, proton inhibitors and surface - protection agents.

«Combination therapy can prevent cytostatic resistance.»

Chemotherapy involves the use of cytostatics, drugs designed to stop cells from dividing and multiplying.

Fluorine is also found in many agrochemicals, and about 20 - 30 % of modern pharmaceuticals, ranging from antimalarial and cytostatic drugs to inhalation anesthetics, blood substitutes, and liquid ventilation agents.

And beyond that, one could make use of the unparalleled spatial and temporal precision of light signaling to activate compounds such as analgesics, cytostatic drugs or anti-diabetic agents only at sites where they are required, thus minimizing unwanted side effects.

Evidence demonstrating its cytostatic activity includes the finding that it inhibits the growth of a broad spectrum of human tumor cell lines in vitro.