Sentences with word «cytotoxic»
"Cytotoxic" refers to something that is toxic or harmful to cells. It can be a substance or treatment that targets and kills cells, often used in the context of chemotherapy or certain medications that aim to destroy cancer cells. Full definition
They compared the number of cytotoxic T cells — which help battle a virus by killing body cells that harbor it — in normal mice and animals missing IL - 33.
sciencemag.org
Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry - Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G. Biologic activity of cytotoxic T lymphocyte - associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.
Chemotherapy for MDS patients involves the use of medicines that kill cells cancer cells called cytotoxic agents.
In laboratory experiments the researchers mimicked the way SOX9 is stabilised in brain tumour cells and showed that SOX9 turned on 40 to 50 genes in the tumour to make it more resistant to standard treatment with cytotoxic drugs and more prone to spread.
Rotavirus - specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes.
In the battle between these two types of immune cells, immunosuppressive lymphocytes win — they use a molecule known as PD - L1 to interfere with cytotoxic T cells.
Thierry Boon and colleagues show that immunogenic mutagenized tumor variants (tum) express new antigens recognized by cytotoxic T lymphocytes (CTLs).
Specifically, TheraT ® has proven to be safe in animals as well as capable of eliciting uniquely potent antigen - specific CD8 + cytotoxic T cell responses and strong tumor control in mice.
Demethylating Agents in Conjunction with Cytotoxic Chemotherapy in Canine Diffuse Large B - cell Lymphoma
The activated T cells, called Cytotoxic T Lymphocytes, then attack and kill tumor cells.
The authors also found that reactivation of the anti-tumor response in cytotoxic memory T cells requires the DC1 subtype of dendritic cells.
: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.
Thus, STxB is a highly specific transport vehicle for cytotoxic agents in gastric carcinoma.
Here we describe the development and preclinical characterization of a CD123 - targeting antibody - drug conjugate (ADC), IMGN632, that comprises a novel humanized anti-CD123 antibody G4723A linked to a recently reported DNA mono - alkylating payload of the indolinobenzodiazepine pseudodimer (IGN) class of cytotoxic compounds.
One way in which cancer cells flourish is by concealing themselves against cytotoxic immune cells.
«A higher number of mature cytotoxic T cells in the body has been associated with age - related, autoimmune, and inflammatory diseases,» added Ott, who is also a professor in the Department of Medicine at the UC San Francisco.
They induce CD4 + helper T cell responses, which in turn activate cytotoxic T cells and direct them to recognize and fight specific types of cancer.
Our data obtained with the MTT assay suggest a non-specific cytotoxic effect of long term (3 days) treatments of both endothelial and tumor cells with micromolar concentrations of kahweol.
Unexpectedly, X-ADC treatment was > 40-fold more cytotoxic to the normal myeloid progenitors than IMGN632 (median IC90 values of 45 pM vs 1900 pM, respectively, in matched samples).
Laboratory hazards and how they should be handled are listed in the regulations such as carcinogenic and teratogenic substances, mercury and its compounds, cytotoxic chemicals, carbon monoxide, lead and its derivatives, and materials that can be absorbed through the skin.
No targeted therapy has been approved for noninflammatory and inflammatory triple - negative breast cancer tumors, and the standard of therapy for these tumors is a combination of conventional cytotoxic chemotherapeutic agents.
(26) These studies also show that cadmium reduces insulin levels and has direct cytotoxic effects on the pancreas.
At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization.
«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.
A suitable molecule with cytotoxic properties against tumors is the biomolecule gramicidin S (GS), a natural antibiotic.
Autoimmune disorders, which may manifest with granulomas on both the skin and other surfaces, are treated corticosteroids to reduce any inflammation and with chemotherapy, using cytotoxic drugs to suppress the immune system.
Platelets mediate cytotoxic T lymphocyte - induced liver damage.
Positive clones were then differentiated using defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.
These vaccines aim to produce cytotoxic T - lymphocytes that will kill HIV - infected cells.
In addition, at a high cytotoxic concentration (50 nM), ActD has been shown to block transcription and decrease levels of HDM2 thereby stabilizing p53 [15].
This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand.
Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.
«PD - L1 allows immunosuppressive lymphocytes to suppress cytotoxic T cells, but it's also their «Achilles heel,»» said Karin, who is also the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.
The researchers found that NASH - associated mutations provoke the immune system, including cytotoxic T cells, to recognize and attack the newly emerging cancer cells.
Curcumin's anticancer effect is attributed to its ability to induce apoptosis in cancer cells without cytotoxic effects on healthy cells.
The CNIC research team generated cytotoxic memory T cells specifically targeting cancer by using different methods for vaccination with tumor antigens.
Slava Stamova (Rieber, TUD)-- «Polyclonal tumor - specific activation of cytotoxic effector cells by bispecific antibody constructs» (2009)
Furthermore, niclosamide proved cytotoxic for glioblastoma and myelogeneous leukemia stem cells as well as NSCLC cells via NFκB and generation of reactive oxygen species (ROS)[37 - 39].
In the Institute of Biochemistry of Lausanne he worked on immunity against infections and1973 - 75 at the Australian National University, Canberra, where Peter Doherty and he made seminal observations on how cytotoxic T cells recognize virus infected cells in an infected host (Nobel Prize for Physiology or Medicine 1996).
Two cytotoxic conjugates STxB - doxorubicin (STxB - Doxo) and STxB - monomethyl auristatin F (STxB - MMAF) were synthesised using copper - free «click» chemistry.
15d - PGJ2 induced significant G2 / M arrest, and exerted time - and dose - dependent cytotoxic effects against all OS cell lines.
Powerful inhibition of experimental human pancreatic cancers by receptor targeted cytotoxic LH - RH analog AEZS - 108.