Sentences with phrase «cytotoxic t»

Richards, R.L., Rao, M., Wassef, N.M., Glenn, G. M., Rothwell, S. W., Alving, C.R. Liposomes containing lipid A serve as an adjuvant for induction of antibody and cytotoxic T - cell responses against RTS, S malaria antigen.

Alving, C.R., Koulchin, V., Glenn, G.M., Rao, M.R. Liposomes as carriers of peptide antigens: Induction of antibodies and cytotoxic T lymphocytes to conjugated and unconjugated peptides.

Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults

Lymphocytes (T - cells = Thymic lymphocytes = killer T cells (aka CD8 +, cytotoxic T cells) & Helper T cells (aka CD4 +)-RRB- patrol the body constantly looking for suspicious invaders or unnecessary elements through the release of lymphokines.

Despite similar mechanisms of action between CsA and tacrolimus, tacrolimus has been demonstrated to be 10 to 100 times more potent than CsA in its ability to inhibit cytotoxic T lymphocytes and production of IL - 2, IL - 3 and gamma interferon in vitro.

This results in the body having the appropriate balance of T cells where we have the proper ratio of T helper, cytotoxic T cells, killer T cells and T suppressor cells.

Mice and human volunteers who underwent cycles of the Fasting Mimicking Diet had decreased numbers of myeloid cells, the inflammatory immune cells that become more numerous as we age, and increased numbers of cytotoxic T cells, which protect the body against viruses and cancer.

Currently there are several known genes associated with Hashimoto's thyroiditis: cytotoxic T - lymphocyte associated antigen 4 (CTLA - 4), human leukocyte antigens (HLA), protein tyrosine phosphatase 22 (PTPN22) and thyroglobulin receptor gene.

Vitamin D supports the cytotoxic T - cells, otherwise known as the «killer cells.»

Atezolizumab is a PD - L1 antagonist and is designed to block inhibitory T - cell checkpoints and allow cytotoxic T cells to reach the tumor.

Researchers have happened upon a previously unknown protein shown to ramp up the presence of all - important cytotoxic T cells, which destroy virus - infected and cancerous cells.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.

Natural killer (NK) cells, the «rapid response» cells of the innate immune system, can kill virally infected cells and thereby slow down an infection until antigen - specific and clonally - expanded cytotoxic T cells can be recruited to finish the job.

Favorable responses with minimal toxicities in monotherapy trials have led to the first melanoma studies of T - VEC in combination with the cytotoxic T - lymphocyte — associated antigen 4 inhibitor ipilimumab and, separately, with the programmed death 1 — blocking antibody pembrolizumab.

Together, they are designed to induce a synergistic anti-tumor cytotoxic T lymphocyte (CTL) response targeting NY - ESO -1-expressing tumors.

[3,4] Dummer et al demonstrated BCG - induced increases in melan - A — specific cytotoxic T cells.

In SIV - infected macaques, Picker's team found that a CMV - based vaccine cleared the virus in 50 % of the monkeys by eliciting and maintaining a powerful, but non-traditional, cytotoxic T - cell response.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

In cancer, Tregs are recruited by tumors and prevent other types of T cells, including cytotoxic T cells (also called CD8 cells) from attacking and destroying cancer cells.

CD8 + cells — also called cytotoxic T - lymphocytes (CTLs)-- matter because, among other actions, they kill cells that become infected with HIV.

This is associated with a relative reduction in cytotoxic T - cell activity and a reduced capacity to destroy infected host cells and clear the virus from infected lung tissue.

Platelets mediate cytotoxic T lymphocytes - induced liver damage.

New CFSE - based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.

We also investigate the mechanisms that in dendritic cells allow for early endosomal escape of antigens leading to subsequent crosspresentation to CD8 + cytotoxic T lymphocytes.

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).

A targeted approach will develop vaccines that can reverse these age - related changes in T - cell responses, particularly the functions of cytotoxic T lymphocytes.

Precursors of human CD4 + cytotoxic T lymphocytes identified by single - cell transcriptome analysis.

These approaches are designed to generate strong, tumor - specific cytotoxic T lymphocytes (CTLs) and attempt to overcome shortcomings of other approaches.

Under certain circumstances, however, a portion of helper T cells turns into cytotoxic T cells (CD4 - CTLs).

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

In addition, studies showed that the elimination of residual leukemia was primarily mediated by donor CD8 + cytotoxic T lymphocytes and NK cells, whereas the inflammatory cytokines that are secreted mainly by CD4 + Th cells have a very limited role in leukemia eradication but contribute significantly to the toxicity of GVHD (55).

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

The researchers demonstrated this by temporarily getting rid of the immune system's cancer - killing cells, called CD8 + or cytotoxic T cells, and showing that without these cells, the virus killed only the initial five percent of cancer cells.

DNA methyltransferase inhibition upregulates MHC - I to potentiate cytotoxic T lymphocyte responses in breast cancer.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Role in suppression of cytotoxic T lymphocyte response and viral persistence.

The films are «Killing Cancer: Cytotoxic T - Cells on Patrol» by Alex Ritter, NIH Oxford - Cambridge Scholars Program; «Companions in Discovery» by Amy Gladfelter, Dartmouth; and «Cell Repair» by Bill Bement, University of Wisconsin, Madison.

Thus, current efforts have focused on finding novel targets to improve cytotoxic T cell activity that will augment existing therapies.

Target - cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes.

Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor.

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.

Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.

Targeting inhibitory proteins within cytotoxic T cells as a means to improve T cell activity against cancer has led to impressive clinical successes, but only in a minority of treated patients (1).

This has resulted in accelerated research focused on understanding the mechanisms that tumors use to inactivate cytotoxic T cells and developing ways to overcome this inhibition (2, 3).

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis - dependent target cell killing.

Depletion of neutrophils blocks the recruitment of antigen - nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.

(PMID: 9802976) Download PDF [ii] Ogg GS, Rod Dunbar P, Romero P, Chen JL, Cerundolo V. High frequency of skin - homing melanocyte - specific cytotoxic T lymphocytes in autoimmune vitiligo.

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.