Sentences with phrase «cytotoxic activity in»

Long - Term Intake of a Low - Casein Diet is Associated With Higher Relative NK Cell Cytotoxic Activity in F344 Rats.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

Not exact matches

Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry - Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G. Biologic activity of cytotoxic T lymphocyte - associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.

Blocking chemokine responsive to -LCB- gamma -RCB--- 2 / interferon (IFN)- -LCB- gamma -RCB- inducible protein and monokine induced by IFN --LCB- gamma -RCB- activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus — specific cytotoxic T lymphocytes.

Poliovirus - specific CD4 + Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

Targeting inhibitory proteins within cytotoxic T cells as a means to improve T cell activity against cancer has led to impressive clinical successes, but only in a minority of treated patients (1).

This is associated with a relative reduction in cytotoxic T - cell activity and a reduced capacity to destroy infected host cells and clear the virus from infected lung tissue.

In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

In order to confirm that the cytotoxic effect seen in the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (FiIn order to confirm that the cytotoxic effect seen in the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fiin the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fiin the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fig.

Conclusions: We demonstrated that rifaximin, neither disrupts the overall biostructure of the human microbiota nor exerts any cytotoxic or genotoxic activities, but it does provoke changes in bacterial metabolism and bifidobacterial numbers that support a functional advantage to the host.

Yes, an evaluation of the cytotoxic and genotoxic activity of yerba maté on human white blood cells found it caused a significant increase in the rate of cell death.

In fact at the doses used, the chemotherapy is not having direct cytotoxic activity, i.e. not directly killing the cancer cells.