Sentences with phrase «cytotoxic conjugates»
Two cytotoxic conjugates STxB - doxorubicin (STxB - Doxo) and STxB - monomethyl auristatin F (STxB - MMAF) were synthesised using copper - free «click» chemistry.
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Following uptake into target cells, conjugates made with the PEG4Mal linker were processed to a cytotoxic metabolite that was retained by MDR1 - expressing cells better than a metabolite of similar conjugates prepared with the nonpolar linker N - succinimidyl - 4 -(maleimidomethyl) cyclohexane -1-carboxylate (SMCC).
Alving, C.R., Koulchin, V., Glenn, G.M., Rao, M.R. Liposomes as carriers of peptide antigens: Induction of antibodies and cytotoxic T lymphocytes to conjugated and unconjugated peptides.