Sentences with phrase «cytotoxic effect of»

Thus, the molecule's observed «effect» on cell growth is nothing more than the well - known cytotoxic effect of alcohol.

Cytotoxic effects of bilberry extract on MCF7 - GFP - tubulin breast cancer cells.

ATM and ATR protein kinase activity confers cellular resistance to the cytotoxic effects of the anthelminthic drug niclosamide.

In addition, they have not only the ability to secrete immunosuppressive cytokines that regulate T cell function, but they also have the capacity to suppress the cytotoxic effects of natural killer cells.

The goal was to deepen the knowledge about the pharmacological and cytotoxic effects of the drug Temodex in vitro in different human brain cancer cell lines.

One study examined the cytotoxic effects of different types of clove extract on breast cancer cell lines, including water - based, alcohol - based and essential oil extracts.

Not exact matches

The researchers demonstrate that the use of specific cytotoxic substances can also have a beneficial effect on the body's immune system.

«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.

Furthermore, they may be cytotoxic or may instead exert an anticancer effect by acting on one or more aspects of the tumor microenvironment either alone or in combination with existing anticancer treatments [3, 4].

SENS Foundation is funding ongoing work in the lab of Dr. Janko Nikolich - Zugich to investigate the effects of clearance of anergic, «senescent» cytotoxic CD8 + T - cells on immunosenescence, (22) and is interested in the targeting of other such cells.

Thus apart from direct cytotoxic effect, the exposure of cancer cells to therapeutic doses of radiation also enhances the survival and proliferation of a fraction of cells which ultimately leads to radiation resistance and therapeutic inefficacy.

Fibrils did not exert a cytotoxic effect over 72 h of culture.

In all these in vitro assays, kahweol treatments were carried out under conditions (kahweol concentration and duration of treatment) that did produce no cytotoxic effect on cells.

: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

Importantly, this automated screening assay allowed us to interrogate some of the specific molecular mechanisms that may be responsible for the targeted cytotoxic effect amiodarone HCL had on NSCs and not cells differentiated from NSCs.

In order to confirm that the cytotoxic effect seen in the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fig.

The main anti-tumour effect of ascorbic acid is due to its production of cytotoxic hydrogen peroxide [16].

The H2 concentration has been as high 98.87 percent H2 and 1.26 percent of O2, at 19.1 atm with minimal to no adverse or cytotoxic effects.

Out of 600 - plus scientific studies, H2 has shown no cytotoxic effects or cytotoxic by - products in the human body.