Single -
cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to
cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (
effector memory T
cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T
cells in the central memory (TCM) and
effector memory (TEM) subsets.